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Effects of long-term sensory vs. sympathetic denervation on the distribution of calcitonin gene-related peptide and tyrosine hydroxylase immunoreactivities in the rat lung.

Abstract：

:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long-term chemosympathectomy a marked increase of CGRP-immunoreactive nerve fibers was seen in the sections, while TH-immunoreactive nerve fibers appeared depleted. Inversely, long-term sensory denervation resulted in an increase of TH-immunoreactive nerve fibers with a sharp decrease of CGRP-immunostained fibers. These results suggest a peripheral interaction between these innervation systems in the lung, the mechanism of which has still to be elucidated.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Van Ranst L,Lauweryns JM

doi

10.1016/0165-5728(90)90155-g

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

131-8

issue

1-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(90)90155-G

journal_volume

29

pub_type

杂志文章

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