Effect of rhTNF-alpha injection into rat sciatic nerve.

abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

journal_title：Journal of neuroimmunology

authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

更新日期：2010-09-14 00:00:00

abstract：:Fibrinolytic activity in the form of plasminogen activator (PA) was assessed using a histochemical fibrin slide technique in spinal cords of normal Lewis rats and rats with the cell-transferred form of experimental allergic encephalomyelitis (EAE). PA was localized exclusively to blood vessels. Vessels in the leptomen...

journal_title：Journal of neuroimmunology

authors： Koh CS,Kwaan HC,Paterson PY

更新日期：1990-08-01 00:00:00

abstract：:To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with hyaluronidase. Induction of meningitis resulted in an upregulation of both pro- and matur...

journal_title：Journal of neuroimmunology

authors： Zwijnenburg PJ,van der Poll T,Florquin S,Akira S,Takeda K,Roord JJ,van Furth AM

更新日期：2003-05-01 00:00:00

abstract：:Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, are widely prescribed for their cholesterol-lowering properties to reduce atherogenesis and cardiovascular morbidity. Over recent years, statins have also been shown to exert pleiotropic immunomodulatory effects that might be of therapeutic benefi...

journal_title：Journal of neuroimmunology

authors： Weber MS,Youssef S,Dunn SE,Prod'homme T,Neuhaus O,Stuve O,Greenwood J,Steinman L,Zamvil SS

更新日期：2006-09-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN), an autoimmune inflammatory demyelinating disease of the peripheral nervous system, represents an animal model of the human Guillain-Barré syndrome. EAN can be induced by active immunization in several animals, including Lewis rats. In contrast, most strains of mice including the...

journal_title：Journal of neuroimmunology

authors： Zhu J,Zou L,Zhu S,Mix E,Shi F,Wang H,Volkmann I,Winblad B,Schalling M,Ljunggren H

更新日期：2001-04-02 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells ...

journal_title：Journal of neuroimmunology

authors： Peron JP,Yang K,Chen ML,Brandao WN,Basso AS,Commodaro AG,Weiner HL,Rizzo LV

更新日期：2010-10-08 00:00:00

abstract：:DNA synthesis was studied in primary glial cell cultures derived from adult human non-neoplastic and neoplastic brain tissues. Enhanced DNA synthesis occurred in 5/5 non-neoplastic astrocyte, one oligodendroglioma, and 2/5 astrocytoma cultures after exposure to medium containing 1.25-12.5% supernatant fluid (SF) from ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Ransohoff RM,Hahn JF,Bay JW

更新日期：1985-12-01 00:00:00

abstract：:Transmitters and cotransmitters of the sympathetic nervous system are involved in the regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli lead to the release of these molecules in immune organs. In this study, we investigated whether local ischemia can cause the parallel re...

journal_title：Journal of neuroimmunology

authors： Sperlágh B,Dóda M,Baranyi M,Haskó G

更新日期：2000-11-01 00:00:00

abstract：:The proNGF peptides LIP1 and LIP2 display multiple biological and physiological properties several of which share common features with the nerve growth factor (NGF). The objective of this study was firstly to demonstrate the presence of these peptides in the human sera and secondly to provide evidence for their involv...

journal_title：Journal of neuroimmunology

authors： Dicou E

更新日期：2008-02-01 00:00:00

abstract：:Immunoelectron microscopical techniques have been used to study class II major histocompatibility complex (MHC) expression by cells in the spinal cords of Biozzi AB/H mice with chronic relapsing experimental allergic encephalomyelitis. Throughout the course of disease both astrocytes and endothelia failed to express s...

journal_title：Journal of neuroimmunology

authors： Butter C,O'Neill JK,Baker D,Gschmeissner SE,Turk JL

更新日期：1991-07-01 00:00:00

abstract：:The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic side effects are found. The present experiments examined the effects of ...

journal_title：Journal of neuroimmunology

authors： Branisteanu DD,Waer M,Sobis H,Marcelis S,Vandeputte M,Bouillon R

更新日期：1995-09-01 00:00:00

abstract：:Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, ...

journal_title：Journal of neuroimmunology

authors： Hilliard A,Mendonca P,Soliman KFA

更新日期：2020-08-15 00:00:00

abstract：:Aspects of gene-environment interactions in multiple sclerosis (MS) were analysed in serum samples from 46 MS families (25 sporadic MS cases and 42 familial MS cases): antibodies to the MS-associated human endogenous retrovirus HERV-H, and levels of three components in the innate pathogen-associated molecular pattern ...

journal_title：Journal of neuroimmunology

authors： Christensen T,Petersen T,Thiel S,Brudek T,Ellermann-Eriksen S,Møller-Larsen A

更新日期：2007-02-01 00:00:00

abstract：:Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and isc...

journal_title：Journal of neuroimmunology

authors： Frauenknecht K,Bargiotas P,Bauer H,von Landenberg P,Schwaninger M,Sommer C

更新日期：2010-10-08 00:00:00

abstract：:Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrol...

journal_title：Journal of neuroimmunology

authors： Smeralda CL,Gigli GL,Vogrig A,Marini A,Valente M

更新日期：2019-05-15 00:00:00

abstract：:Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

journal_title：Journal of neuroimmunology

authors： Armstrong ME,Loscher CE,Lynch MA,Mills KH

更新日期：2003-03-01 00:00:00

abstract：:CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leuko...

journal_title：Journal of neuroimmunology

authors： Thelen M,Thelen S

更新日期：2008-07-31 00:00:00

abstract：:In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

journal_title：Journal of neuroimmunology

authors： Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

更新日期：1998-02-01 00:00:00

abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

更新日期：2015-06-15 00:00:00

abstract：:Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

journal_title：Journal of neuroimmunology

authors： Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

更新日期：2017-10-15 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investi...

journal_title：Journal of neuroimmunology

authors： Peelen E,Thewissen M,Knippenberg S,Smolders J,Muris AH,Menheere P,Tervaert JW,Hupperts R,Damoiseaux J

更新日期：2013-05-15 00:00:00

abstract：:This study examined the immunoregulatory effects of anadamide, the recently identified first endogenous cannabinoid receptor ligand. Anadamide caused dose-dependent inhibition of mitogen-induced T and B lymphocyte proliferation. Its potency was 3- and 10-fold less than that of the synthetic cannabinoids delta 8-tetrah...

journal_title：Journal of neuroimmunology

authors： Schwarz H,Blanco FJ,Lotz M

更新日期：1994-11-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

journal_title：Journal of neuroimmunology

authors： Conrady CD,Drevets DA,Carr DJ

更新日期：2010-03-30 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Irazoqui FJ,Nores GA

更新日期：2000-06-26 00:00:00

abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

journal_title：Journal of neuroimmunology

authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

更新日期：2010-12-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

journal_title：Journal of neuroimmunology

authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

更新日期：2004-01-01 00:00:00

abstract：:This study examined the mechanism by which exposure to lipopolysaccharide (LPS) alters mu-opioid receptor (MOR) expression in immune and neuronal cells using an in vitro conditioned medium model system. We found that LPS stimulated the intracellular accumulation of reactive oxygen species (ROS) and MOR expression in m...

journal_title：Journal of neuroimmunology

authors： Langsdorf EF,Mao X,Chang SL

更新日期：2011-07-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of adenos...

journal_title：Journal of neuroimmunology

authors： Ahmad S,Elsherbiny NM,Bhatia K,Elsherbini AM,Fulzele S,Liou GI

更新日期：2014-12-15 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00