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Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.

Abstract：

:A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of significance. In the present study, using a combined all-Spain collection of 2515 MS patients and 2942 healthy controls, we demonstrate significant association of rs17824933 in CD6 (P(CMH)=0.004; OR=1.14; 95% CI 1.04-1.24) and of rs1860545 in TNFRSF1A (P(CMH)=0.001; OR=1.15; 95% CI 1.06-1.25) with MS, while the low-frequency coding non-synonymous SNP rs4149584 in TNFRSF1A displayed a trend for association (P(CMH)=0.062; OR=1.27; 95% CI 0.99-1.63). This data reinforce a generic role for CD6 and TNFRSF1A in susceptibility to MS, extending to populations of southern European ancestry.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

doi

10.1016/j.jneuroim.2010.03.020

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

100-3

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00132-3

journal_volume

223

pub_type

杂志文章

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