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Treatment with atacicept enhances neuronal cell death in a rat model of optic neuritis.

Abstract：

:We investigated the effect of atacicept, a recombinant fusion protein blocking BLyS and APRIL and acting on B cells, on degeneration of retinal ganglion cells (RGCs) during experimental autoimmune encephalomyelitis (EAE). We used myelin oligodendrocyte glycoprotein in Brown Norway rats to induce a variant of EAE which involves B cells and leads to severe optic neuritis. Intraperitoneal treatment with atacicept at some of the studied dose levels (100 or 200 μg) resulted in increased apoptosis of retinal ganglion cells whereas at a tenfold lower dose or in vehicle-treated animals no such effect became apparent. Also the extent of inflammation, demyelination, and axonal loss of the optic nerve was more pronounced in rats treated with the higher atacicept dose level. The present study describes observational evidence for adverse effects of atacicept on neuronal survival during EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kretzschmar B,Hein K,Moinfar Z,Könnecke B,Sättler MB,Hess H,Weissert R,Bähr M

doi

10.1016/j.jneuroim.2014.01.005

subject

Has Abstract

pub_date

2014-03-15 00:00:00

pages

58-63

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(14)00008-3

journal_volume

268

pub_type

杂志文章

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