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Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

Abstract：

:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

doi

10.1016/j.jneuroim.2017.06.001

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

17-25

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(17)30096-6

journal_volume

310

pub_type

杂志文章

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