Abstract：
:To investigate immune mechanisms in the etiology of idiopathic sensory neuronopathy (ISN), we studied neurite outgrowth inhibition and antibody binding to neuronal tissue of serum from 4 patients with ISN. Rat dorsal root ganglion (DRG) cells were cultured in the presence of serum from ISN patients and controls. After 48 h of incubation, neurite outgrowth was quantified with a neurofilament ELISA. Serum from ISN patients significantly inhibited DRG neurite outgrowth compared to controls. ISN serum also strongly immunostained fixed cultured and cryostat rat DRG neurons (at dilutions up to 1:10,240), whereas serum from controls did not. Western blots showed unique binding patterns to DRG proteins in 3 ISN patients compared with controls, but a single band corresponding in all ISN patients was not found. The inhibitory effect of ISN serum on neurite outgrowth and the presence of circulating anti-DRG antibodies in the acute phase of the disease supports an immune-mediated pathogenesis of ISN.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
van Dijk GW,Wokke JH,Notermans NC,van den Berg LH,Bär PRdoi
10.1016/s0165-5728(96)00225-1subject
Has Abstractpub_date
1997-04-01 00:00:00pages
165-72issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(96)00225-1journal_volume
74pub_type
杂志文章abstract：OBJECTIVE:The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation. METHODS:1529 MS patients and 1814 controls from Sweden and Norway were g...
journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2014-08-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jneuroim.2012.03.013
更新日期：2012-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0165-5728(00)00451-3
更新日期：2001-02-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2010.04.006
更新日期：2010-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jneuroim.2005.09.018
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pub_type： 杂志文章
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更新日期：2009-01-03 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2011.08.009
更新日期：2011-10-28 00:00:00
abstract：:Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populati...
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