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PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.

Abstract：

:Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE). PD-1-/- and PD-L1-/- mice developed more severe EAE than wild type and PD-L2-/- mice. Consistent with this, PD-1-/- and PD-L1-/- cells produced elevated levels of the pro-inflammatory cytokines IFN-gamma, TNF, IL-6 and IL-17. These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Carter LL,Leach MW,Azoitei ML,Cui J,Pelker JW,Jussif J,Benoit S,Ireland G,Luxenberg D,Askew GR,Milarski KL,Groves C,Brown T,Carito BA,Percival K,Carreno BM,Collins M,Marusic S

doi

10.1016/j.jneuroim.2006.10.006

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

124-34

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00390-0

journal_volume

182

pub_type

杂志文章

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