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The differential expression and potential roles of circular RNAs in children with anti-NMDA receptor encephalitis.

Abstract：

:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p < .05) were dysregulated in anti-NMDA receptor encephalitis patients, relative to healthy controls, based on microarray data. Further bioinformatic analysis demonstrated that the host genes of dysregulated circRNAs are primarily associated with receptor internalization. In conclusion, circRNAs may be implicated in the pathogenesis of pediatric anti-NMDA receptor encephalitis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

doi

10.1016/j.jneuroim.2020.577381

subject

Has Abstract

pub_date

2020-11-15 00:00:00

pages

577381

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(20)30488-4

journal_volume

348

pub_type

杂志文章

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