Abstract:
:Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammation, demyelination, and axonal degeneration may underlie this exacerbation. In addition, we report that males exhibit greater CNS inflammation and higher numbers of demyelinating lesions while females show greater susceptibility to RS-induced exacerbation. These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Young EE,Sieve AN,Vichaya EG,Carcoba LM,Young CR,Ambrus A,Storts R,Welsh CJ,Meagher MWdoi
10.1016/j.jneuroim.2010.01.015subject
Has Abstractpub_date
2010-03-30 00:00:00pages
79-89issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(10)00036-6journal_volume
220pub_type
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