Intrathecal rituximab in immunoglobulin G4-hypertrophic pachymeningitis.

abstract：:We previously reported that interleukin-4 (IL-4) inhibited proliferation of a human astrocytic cell line derived from non-neoplastic adult cortex. To determine whether this effect was receptor-associated and/or limited to only non-neoplastic astrocytes, we examined IL-4 responsiveness and receptor expression in human ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Estes ML,Pettay J,Iwasaki K,Zhou P,Barnett GH

更新日期：1995-07-01 00:00:00

abstract：:Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equine encephalitis virus (VEEV)...

journal_title：Journal of neuroimmunology

authors： Cain MD,Salimi H,Gong Y,Yang L,Hamilton SL,Heffernan JR,Hou J,Miller MJ,Klein RS

更新日期：2017-07-15 00:00:00

abstract：:This report is to alert other investigators that Lewis rats, which are widely employed in studies of autoimmune diseases, vary considerably with respect to susceptibility to experimental autoimmune encephalomyelitis (EAE), depending upon commercial source. ...

journal_title：Journal of neuroimmunology

authors： Gould KE,Stepaniak JA,Swanborg RH

更新日期：1994-10-01 00:00:00

abstract：:Changes in mitogen-induced splenocyte proliferation and NK activity were evaluated after acute (1 h) and chronic (6 d) in vivo treatment of rats with the synthetic cannabinoid compound CP-55,940. At a dose of 0.4 mg/kg i.p. it significantly inhibited the splenocyte proliferative response to PHA and NK activity but hal...

journal_title：Journal of neuroimmunology

authors： Patrini G,Sacerdote P,Fuzio D,Manfredi B,Parolaro D

更新日期：1997-12-01 00:00:00

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:Peptide p259-271 of the human acetylcholine receptor alpha-subunit, preferentially stimulates T cells of patients with myasthenia gravis (MG) and is an immunodominant epitope for T cells of BALB/c mice. A p259-271 specific T cell line of BALB/c origin was established and was shown to induce experimental MG in naive mi...

journal_title：Journal of neuroimmunology

authors： Katz-Levy Y,Dayan M,Wirguin I,Fridkin M,Sela M,Mozes E

更新日期：1998-05-01 00:00:00

abstract：:Previous work in our laboratory has shown that cytokine production by primary murine macrophages, and macrophage cell lines, is inhibited following treatment with the kappa-opioid agonist U50,488H. Furthermore, we have found that the participation of both accessory cells and T cells in an antibody response is suppress...

journal_title：Journal of neuroimmunology

authors： Guan L,Eisenstein TK,Adler MW,Rogers TJ

更新日期：1997-05-01 00:00:00

abstract：:Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate...

journal_title：Journal of neuroimmunology

authors： Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

更新日期：2004-02-01 00:00:00

abstract：:The capacity of rat cerebral endothelial cells (RCEC) to form eicosanoids was determined after incubation with 14C-labelled arachidonic acid. Prostaglandin E2 (PGE2) was the main metabolite formed by RCEC and was responsible for 54% of the total amount of eicosanoids produced. In contrast, in primary cultures of rat a...

journal_title：Journal of neuroimmunology

authors： de Vries HE,Hoogendoorn KH,van Dijk J,Zijlstra FJ,van Dam AM,Breimer DD,van Berkel TJ,de Boer AG,Kuiper J

更新日期：1995-06-01 00:00:00

abstract：:Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined the relevance of pha...

journal_title：Journal of neuroimmunology

authors： Shi F,Yang Y,Kouadir M,Fu Y,Yang L,Zhou X,Yin X,Zhao D

更新日期：2013-07-15 00:00:00

abstract：:Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

journal_title：Journal of neuroimmunology

authors： Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

更新日期：2014-03-15 00:00:00

abstract：:B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

journal_title：Journal of neuroimmunology

authors： Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

更新日期：2010-02-26 00:00:00

abstract：:To address the role of different intracellular signals in prolactin (PRL) expression in leukocytes, we have investigated the effects of chlorophenylthio-cAMP (cptcAMP), phorbol myristate acetate (PMA) and ionomycin on the activation of the upstream PRL promoter in several leukemic cell lines. All three stimulators, al...

journal_title：Journal of neuroimmunology

authors： Gerlo S,Vanden Berghe W,Verdood P,Hooghe-Peters EL,Kooijman R

更新日期：2003-02-01 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:We studied the effect of acute (1 h) or chronic exposure (7 and 14 days) to delta9-tetrahydrocannabinol (delta9-THC) on immune parameters in male Swiss mice. One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in...

journal_title：Journal of neuroimmunology

authors： Massi P,Sacerdote P,Ponti W,Fuzio D,Manfredi B,Viganó D,Rubino T,Bardotti M,Parolaro D

更新日期：1998-12-01 00:00:00

abstract：:The in vivo relationship of interleukin-2 (IL-2) to the local humoral immune response within the central nervous system (CNS) in patients with multiple sclerosis (MS) is hitherto largely unknown. Intrathecal levels of IL-2 and soluble IL-2 receptors (sIL-2R) were correlated to the local CNS synthesis of immunoglobulin...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Hentges R,Thompson EJ

更新日期：1991-04-01 00:00:00

abstract：:The present investigations sought to determine whether the ventral tegmental area (VTA), basolateral amygdala (BLA), and nucleus accumbens shell (NAC) comprise a circuitry that mediates heroin-induced conditioned immunomodulation. Rats were given conditioning trials in which they received an injection of heroin upon p...

journal_title：Journal of neuroimmunology

authors： Szczytkowski JL,Fuchs RA,Lysle DT

更新日期：2011-08-15 00:00:00

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:High doses of glucocorticoids (GCs) are widely employed to treat acute attacks in relapsing-remitting multiple sclerosis (MS) patients. Their beneficial effects are partially due to their capacity to regulate the cytokine network. In the present work, we have examined the effect of GCs on the production of the immunos...

journal_title：Journal of neuroimmunology

authors： Gayo A,Mozo L,Suárez A,Tuñon A,Lahoz C,Gutiérrez C

更新日期：1998-05-15 00:00:00

abstract：:Neutrophil activity was elevated in the conditioned mice for the first time through an established conditioned training process. Catecholamines were proved to be important in the regulation of this conditioned innate immunity. In the study, the camphor odor (as the conditioned stimulus, CS) and poly I: C (as the uncon...

journal_title：Journal of neuroimmunology

authors： Chao HJ,Hsu YC,Yuan HP,Jiang HS,Hsueh CM

更新日期：2005-01-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammat...

journal_title：Journal of neuroimmunology

authors： Young EE,Sieve AN,Vichaya EG,Carcoba LM,Young CR,Ambrus A,Storts R,Welsh CJ,Meagher MW

更新日期：2010-03-30 00:00:00

abstract：:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

journal_title：Journal of neuroimmunology

authors： Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

更新日期：2016-03-15 00:00:00

abstract：:Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat...

journal_title：Journal of neuroimmunology

authors： Saab CY,Shamaa F,El Sabban ME,Safieh-Garabedian B,Jabbur SJ,Saadé NE

更新日期：2009-03-31 00:00:00

abstract：:Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central...

journal_title：Journal of neuroimmunology

authors： Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

更新日期：1993-11-01 00:00:00

abstract：:Peripheral blood T cells were isolated from chronic progressive multiple sclerosis patients using a stepwise protocol of density gradient centrifugation, erythrocyte rosetting and adherent cell depletion, after which T cells were cultured with no added stimulus. These cultures exhibited as much as 10-fold higher 'back...

journal_title：Journal of neuroimmunology

authors： Kamin-Lewis RM,Karasanyi N,Koski CL,Lewis GK

更新日期：1994-09-01 00:00:00

abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

journal_title：Journal of neuroimmunology

authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

更新日期：2020-11-15 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

journal_title：Journal of neuroimmunology

authors： Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

更新日期：2006-07-01 00:00:00

abstract：:To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

journal_title：Journal of neuroimmunology

authors： Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

更新日期：2000-04-03 00:00:00

abstract：:Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrie...

journal_title：Journal of neuroimmunology

authors： Walker-Caulfield ME,Hatfield JK,Brown MA

更新日期：2015-01-15 00:00:00