当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.

Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.

Abstract：

:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduced Th17 and increased Treg cell percentages along with the levels of associated cytokines. Molecules involved in cellular metabolism were altered in mice with EAE. Suppressed activation of mTOR and its downstream target, HIF-1α, likely mediated the protective effects of metformin. Our findings demonstrate that regulation of T cell metabolism represents a new therapeutic target for CNS autoimmune disorders.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

doi

10.1016/j.jneuroim.2016.01.014

subject

Has Abstract

pub_date

2016-03-15 00:00:00

pages

58-67

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30010-8

journal_volume

292

pub_type

杂志文章

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