当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.

Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.

Abstract：

:Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central nervous system (CNS) infections and four without CNS infection). In this study levels of sTNFR-p55, sTNFR-p75 and sCD25 were elevated in the CSF of ADC patients and of the 11 patients with other CNS infections, whereas CSF-levels of the specific T cell marker sCD27 were lower in patients with ADC as compared to the control subjects with and without other CNS infections. This pattern suggests a relative failure of eliciting a T cell-mediated immune response intrathecally in patients with ADC.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

doi

10.1016/0165-5728(93)90198-8

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

241-7

issue

2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(93)90198-8

journal_volume

48

pub_type

杂志文章

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