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The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.

Abstract：

:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lung weight)/(Ppc) ratio in the ICV-vehicle/LPS group at 4h. There were decreases in TLR4 pathway markers, such as interleukin receptor-associated kinase-1, IκBα, Raf1 and phospho-SFK (Tyr416) at 30min and at 4h increases in IL-6, vascular cell adhesion molecule-1 and myeloperoxidase in lung homogenate. Intracerebroventricular rimonabant attenuated these LPS-induced responses, indicating that ICV rimonabant modulates LPS-initiated pulmonary inflammation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

doi

10.1016/j.jneuroim.2015.07.001

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

16-24

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(15)30003-5

journal_volume

286

pub_type

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