Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats.

abstract：:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

journal_title：Journal of neuroimmunology

authors： Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

更新日期：1989-03-01 00:00:00

abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

journal_title：Journal of neuroimmunology

authors： Whitaker JN,McKeehan A,Freeman DW

更新日期：1994-06-01 00:00:00

abstract：:The BeAn strain of Theiler's murine encephalomyelitis virus (TMEV) persists in the CNS and produces a chronic inflammatory demyelinating disease that is an animal model for human multiple sclerosis (MS). The mechanisms leading to TMEV-induced demyelination are still under study but most likely involve both immune-medi...

journal_title：Journal of neuroimmunology

authors： Zheng L,Calenoff MA,Dal Canto MC

更新日期：2001-08-30 00:00:00

abstract：:TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...

journal_title：Journal of neuroimmunology

authors： Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

更新日期：2005-11-01 00:00:00

abstract：:Cytokines such as interleukin-1 (IL-1) are thought to contribute to the inflammatory response associated with autoimmune diseases like multiple sclerosis. We assessed the role of IL-1 in an animal model of MS, experimental allergic encephalomyelitis (EAE), by testing the effects of treatment with an IL-1 receptor anta...

journal_title：Journal of neuroimmunology

authors： Martin D,Near SL

更新日期：1995-09-01 00:00:00

abstract：:In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myeli...

journal_title：Journal of neuroimmunology

authors： Vergelli M,Kalbus M,Rojo SC,Hemmer B,Kalbacher H,Tranquill L,Beck H,McFarland HF,De Mars R,Long EO,Martin R

更新日期：1997-08-01 00:00:00

abstract：:Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We o...

journal_title：Journal of neuroimmunology

authors： García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

更新日期：2014-09-15 00:00:00

abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

journal_title：Journal of neuroimmunology

authors： Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

更新日期：2010-05-01 00:00:00

abstract：:Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

journal_title：Journal of neuroimmunology

authors： Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

更新日期：2006-09-01 00:00:00

abstract：:In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

journal_title：Journal of neuroimmunology

authors： Micera A,Properzi F,Triaca V,Aloe L

更新日期：2000-05-01 00:00:00

abstract：:Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS c...

journal_title：Journal of neuroimmunology

authors： Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

更新日期：2017-04-15 00:00:00

abstract：:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

journal_title：Journal of neuroimmunology

authors： Argall KG,Armati PJ,Pollard JD,Bonner J

更新日期：1992-09-01 00:00:00

abstract：:To test the hypothesis of an altered central nervous system influence upon the immune system of Down's syndrome (DS) patients and in order to establish a peripheral biological marker of neuroimmune deficit, we have studied the characteristics of the beta 2-adrenergic receptor (B2AR) system in peripheral blood monocyte...

journal_title：Journal of neuroimmunology

authors： Morale MC,Batticane N,Cioni M,Marchetti B

更新日期：1992-06-01 00:00:00

abstract：:Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate ph...

journal_title：Journal of neuroimmunology

authors： Phan TA,Taylor AW

更新日期：2013-07-15 00:00:00

abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

journal_title：Journal of neuroimmunology

authors： Marra S,Burnett M,Hoffman-Goetz L

更新日期：2005-01-01 00:00:00

abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

journal_title：Journal of neuroimmunology

authors： Akeson R,Graham K

更新日期：1981-09-01 00:00:00

abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

journal_title：Journal of neuroimmunology

authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

更新日期：1982-06-01 00:00:00

abstract：:Axonal injury is the major cause of disability in patients with multiple sclerosis (MS), but the mechanisms leading to axonal damage are poorly understood. Oligoclonal IgM against lipids predicts an aggressive disease course in MS; however, the antigen that elicits the immune response has not yet been identified. We s...

journal_title：Journal of neuroimmunology

authors： Beltrán E,Hernández A,Lafuente EM,Coret F,Simó-Castelló M,Boscá I,Pérez-Miralles FC,Burgal M,Casanova B

更新日期：2012-06-15 00:00:00

abstract：:We describe the case of a 69-year-old man who presented with symptoms of headache and severe vision loss due to G4 immunoglobulin (IgG4) hypertrophic pachymeningitis (HP). The patient was initially responsive to corticotherapy, but vision loss progressed when steroid therapy was first tapered. No improvement was notic...

journal_title：Journal of neuroimmunology

authors： Soares C,Martins DF,Pestana-Silva R,Honavar M,Faria O,Abreu P,Costa A

更新日期：2019-09-15 00:00:00

abstract：:Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139-151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by splee...

journal_title：Journal of neuroimmunology

authors： Santambrogio L,Crisi GM,Leu J,Hochwald GM,Ryan T,Thorbecke GJ

更新日期：1995-05-01 00:00:00

abstract：:T-cell subsets in the peripheral blood were analyzed using monoclonal antibodies during the development of experimental allergic neuritis in Lewis rats. Percentages of helper and suppressor cells and ratios of helper/suppressor cells did not exceed normal limits during the development of the disease. ...

journal_title：Journal of neuroimmunology

authors： Feasby TE,Mazaheri R,Hahn AF,Gilbert JJ,Stiller CR,Keown PA

更新日期：1984-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

journal_title：Journal of neuroimmunology

authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

更新日期：2003-05-01 00:00:00

abstract：:Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

journal_title：Journal of neuroimmunology

authors： Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

更新日期：2017-10-15 00:00:00

abstract：:To illustrate the accuracy of the fluorescence-activated cell sorting cell-based assay (FACS-CBA) and to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies and ascertain the optimal method for positivity judgement, referencing the findings of microscopic CBA. We tested serum anti-MOG antibodies in 57 pat...

journal_title：Journal of neuroimmunology

authors： Sugimoto K,Mori M,Liu J,Tanaka S,Kaneko K,Oji S,Takahashi T,Uzawa A,Uchida T,Masuda H,Ohtani R,Nomura K,Hiwasa T,Kuwabara S

更新日期：2019-11-15 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility C...

journal_title：Journal of neuroimmunology

authors： Sanders V,Conrad AJ,Tourtellotte WW

更新日期：1993-07-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

journal_title：Journal of neuroimmunology

authors： Mehl VS,Lang RW

更新日期：1984-08-01 00:00:00

abstract：:Two synthetic peripheral nerve myelin P0 protein peptides, an immunodominant (amino acids 180-199) and a cryptic (amino acids 56-71) one, induced an acute or chronic course of experimental autoimmune neuritis (EAN) in Lewis rats, when given at low dose (50-100 microg/rat) or high dose (250 microg/rat), respectively. C...

journal_title：Journal of neuroimmunology

authors： Zhu J,Pelidou SH,Deretzi G,Levi M,Mix E,van der Meide P,Winblad B,Zou LP

更新日期：2001-03-01 00:00:00

abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

journal_title：Journal of neuroimmunology

authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

更新日期：2002-01-01 00:00:00