当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay.

IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay.

Abstract：

:We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera. Fifteen CIDP patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by western blot, cell-based assay and immunohistochemical study. None of disease controls or healthy subjects had positive results. Clinical presentation of IgG4 anti-NF155 antibody-positive patients was consistent with those in previous reports. This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kadoya M,Kaida K,Koike H,Takazaki H,Ogata H,Moriguchi K,Shimizu J,Nagata E,Takizawa S,Chiba A,Yamasaki R,Kira JI,Sobue G,Ikewaki K

doi

10.1016/j.jneuroim.2016.10.013

subject

Has Abstract

pub_date

2016-12-15 00:00:00

pages

16-22

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30267-3

journal_volume

301

pub_type

杂志文章

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