Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67).

abstract：:To assess whether TNF-alpha causes inflammatory demyelination or axonal degeneration, we injected into rat sciatic nerve saline, 100 U and 1000 U of rhTNF-alpha and studied the electrophysiological and pathological effects. At day 1 electrophysiology showed a slight reduction of proximal compound muscle action potenti...

journal_title：Journal of neuroimmunology

authors： Uncini A,Di Muzio A,Di Guglielmo G,De Angelis MV,De Luca G,Lugaresi A,Gambi D

更新日期：1999-02-01 00:00:00

abstract：:We report human leukocyte antigen (HLA) class I expression in 5-17% and class II in 0-9% of first trimester human spinal cord cells. After 8 days in culture with gamma-interferon, >87% of the spinal cord cells expressed HLA class II. However, mixed cultures of adult human peripheral lymphocytes and immature human spin...

journal_title：Journal of neuroimmunology

authors： Akesson E,Markling L,Kjaeldgaard A,Falci S,Ringdén O

更新日期：2000-11-01 00:00:00

abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

journal_title：Journal of neuroimmunology

authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

更新日期：2005-03-01 00:00:00

abstract：:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology and pathogenesis of MS and NMOSD remain unclear. The pathogenesis of these two diseases involves a genetic predisposition as well as environmental factors. NMOSD som...

journal_title：Journal of neuroimmunology

authors： Liang H,Gao W,Liu X,Liu J,Mao X,Yang M,Long X,Zhou Y,Zhang Q,Zhu J,Wang S,Jin T

更新日期：2019-12-15 00:00:00

abstract：:To explore the possible contribution of thymic myoid cells in tolerance induction mechanisms, we quantified by real-time RT-PCR, the expression of 12 muscle genes (the five subunits of acetylcholine receptor, Musk, rapsyn, utrophin, ErbB2, ErbB3, troponin T, and MCK) in a human thymic myoid cell line (MITC), compared ...

journal_title：Journal of neuroimmunology

authors： Mesnard-Rouiller L,Bismuth J,Wakkach A,Poëa-Guyon S,Berrih-Aknin S

更新日期：2004-03-01 00:00:00

abstract：:The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methylation of the SHP-1 p...

journal_title：Journal of neuroimmunology

authors： Kumagai C,Kalman B,Middleton FA,Vyshkina T,Massa PT

更新日期：2012-05-15 00:00:00

abstract：:We investigated whether glatiramer acetate (GA) treatment may affect Th1 differentiation at various T-cell maturation stages. Specifically, we analyzed the effect of in vivo GA treatment on intracellular synthesis of IL-2 and TNF-alpha by naive, memory and effector CD4(+) and CD8(+) T cells by five-colour flow cytomet...

journal_title：Journal of neuroimmunology

authors： Kantengwa S,Weber MS,Juillard C,Benkhoucha M,Fellay B,Zamvil SS,Gougeon ML,Chofflon M,Lalive PH

更新日期：2007-04-01 00:00:00

abstract：:Previous work in our laboratory has shown that cytokine production by primary murine macrophages, and macrophage cell lines, is inhibited following treatment with the kappa-opioid agonist U50,488H. Furthermore, we have found that the participation of both accessory cells and T cells in an antibody response is suppress...

journal_title：Journal of neuroimmunology

authors： Guan L,Eisenstein TK,Adler MW,Rogers TJ

更新日期：1997-05-01 00:00:00

abstract：:Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the ...

journal_title：Journal of neuroimmunology

authors： Unoda K,Doi Y,Nakajima H,Yamane K,Hosokawa T,Ishida S,Kimura F,Hanafusa T

更新日期：2013-03-15 00:00:00

abstract：:Patients with small-cell carcinoma of the lung and paraneoplastic encephalomyelitis develop antibodies (anti-Hu) against HuD, a member of a family of neuronal specific RNA-binding proteins, which are also expressed by the tumor. In order to determine if the human HuD paraneoplastic antigen shares immunogenic regions b...

journal_title：Journal of neuroimmunology

authors： Sillevis Smitt P,Manley G,Dalmau J,Posner J

更新日期：1996-12-01 00:00:00

abstract：:To investigate immune mechanisms in the etiology of idiopathic sensory neuronopathy (ISN), we studied neurite outgrowth inhibition and antibody binding to neuronal tissue of serum from 4 patients with ISN. Rat dorsal root ganglion (DRG) cells were cultured in the presence of serum from ISN patients and controls. After...

journal_title：Journal of neuroimmunology

authors： van Dijk GW,Wokke JH,Notermans NC,van den Berg LH,Bär PR

更新日期：1997-04-01 00:00:00

abstract：:Dendritic cells are the critical mediators of various immune responses and are the first line of defense against any infection including HIV. They play a major role in harboring HIV and the subsequent infection of T cells and passage of virus through the blood-brain barrier (BBB). The recently discovered DC-specific, ...

journal_title：Journal of neuroimmunology

authors： Nair MP,Schwartz SA,Mahajan SD,Tsiao C,Chawda RP,Whitney R,Don Sykes BB,Hewitt R

更新日期：2004-12-01 00:00:00

abstract：:The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...

journal_title：Journal of neuroimmunology

authors： Cereda C,Baiocchi C,Bongioanni P,Cova E,Guareschi S,Metelli MR,Rossi B,Sbalsi I,Cuccia MC,Ceroni M

更新日期：2008-02-01 00:00:00

abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

journal_title：Journal of neuroimmunology

authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

更新日期：2018-11-15 00:00:00

abstract：:Contradictory results have been reported regarding the role of inflammatory mediators in the central nervous system in mediating neuropathic pain and inflammatory hyperalgesia following peripheral nerve injury or localized inflammation. The present study aims to correlate between the mRNA expression and protein secret...

journal_title：Journal of neuroimmunology

authors： Chamaa F,Chebaro M,Safieh-Garabedian B,Saadeh R,Jabbur SJ,Saadé NE

更新日期：2016-08-15 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

journal_title：Journal of neuroimmunology

authors： Qiu Z,Gruol DL

更新日期：2003-06-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately...

journal_title：Journal of neuroimmunology

authors： Dijkstra CD,De Groot CJ,Huitinga I

更新日期：1992-10-01 00:00:00

abstract：:We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q au...

journal_title：Journal of neuroimmunology

authors： Yoshikura N,Kimura A,Hayashi Y,Inuzuka T

更新日期：2017-09-15 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:In order to study the role of interleukin-1beta (IL-1beta) in homeostasis, hypoxia and recovery of neuronal cells, we studied the expression and release of tumor necrosis factor-alpha (TNF-alpha) and nerve growth factor (NGF), in relation to the presence or absence of this cytokine in culture medium. Moreover, we eval...

journal_title：Journal of neuroimmunology

authors： Di Loreto S,Corvetti L,Maccarone R,Piancatelli D,Adorno D

更新日期：2000-07-01 00:00:00

abstract：:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurological disease caused by HTLV-I infection. It has been shown that HAM/TSP patients have high proviral loads and an extraordinarily high frequency of circulating CD8 + cytotoxic T lymphocytes...

journal_title：Journal of neuroimmunology

authors： Kubota R,Kawanishi T,Matsubara H,Manns A,Jacobson S

更新日期：2000-01-24 00:00:00

abstract：:To address the role of different intracellular signals in prolactin (PRL) expression in leukocytes, we have investigated the effects of chlorophenylthio-cAMP (cptcAMP), phorbol myristate acetate (PMA) and ionomycin on the activation of the upstream PRL promoter in several leukemic cell lines. All three stimulators, al...

journal_title：Journal of neuroimmunology

authors： Gerlo S,Vanden Berghe W,Verdood P,Hooghe-Peters EL,Kooijman R

更新日期：2003-02-01 00:00:00

abstract：:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

journal_title：Journal of neuroimmunology

authors： Rao D,Vasanthapuram R,Satishchandra P,Desai A

更新日期：2018-05-15 00:00:00

abstract：:Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

journal_title：Journal of neuroimmunology

authors： Vogelgesang A,Dressel A

更新日期：2011-02-01 00:00:00

abstract：:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of...

journal_title：Journal of neuroimmunology

authors： Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

更新日期：2011-07-01 00:00:00

abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

journal_title：Journal of neuroimmunology

authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

更新日期：2006-08-01 00:00:00

abstract：:Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined the relevance of pha...

journal_title：Journal of neuroimmunology

authors： Shi F,Yang Y,Kouadir M,Fu Y,Yang L,Zhou X,Yin X,Zhao D

更新日期：2013-07-15 00:00:00

abstract：:Increases in the levels of proinflammatory cytokines, such as TNF alpha, have been intricately linked with arthritis and the pathogenesis of several models of neuropathic pain. In addition, arthritis (as well as other types of persistent pain) is associated with increased sympathetic activity and alterations of other ...

journal_title：Journal of neuroimmunology

authors： Chou RC,Dong XL,Noble BK,Knight PR,Spengler RN

更新日期：1998-03-01 00:00:00