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How cytokines can influence the brain: a role for chemokines?

Abstract：

:Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence the brain and the behaviors through several possible pathways: modulating peripheral neurons which project to the brain through the vagus nerve, modulating the levels of hormones such as leptin which can act to the brain through the humoral pathway and possibly acting directly in the brain, through the local production of cytokines and chemokines such as SDF-1alpha/CXCL12.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Guyon A,Massa F,Rovère C,Nahon JL

doi

10.1016/j.jneuroim.2008.04.009

subject

Has Abstract

pub_date

2008-07-31 00:00:00

pages

46-55

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00109-4

journal_volume

198

pub_type

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