Abstract:
:We tested the performance of MRZ-reaction, an intrathecal humoral immune response against-Measles (M), Rubella (R) and Varicella Zoster (Z) viruses, in multiple sclerosis (MS) diagnosis. The MRZ-reaction was significantly more positive in MS than in non-MS group with a specificity of 91.9%. In MS group, the RZ-profile was the most prevalent and the R-specific antibody-index was correlated to the number of oligoclonal bands (OCB) in CSF. Interestingly, the MRZ-reaction was detected in 53% of OCB-negative-MS patients. The MRZ-reaction seems to be a relevant CSF diagnostic marker of MS disease. The likely relation between its positivity and the vaccination status deserves to be investigated.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Feki S,Gargouri S,Mejdoub S,Dammak M,Hachicha H,Hadiji O,Feki L,Hammami A,Mhiri C,Karray H,Masmoudi Hdoi
10.1016/j.jneuroim.2018.05.015subject
Has Abstractpub_date
2018-08-15 00:00:00pages
66-71eissn
0165-5728issn
1872-8421pii
S0165-5728(18)30068-7journal_volume
321pub_type
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