Abstract:
:We present a 53-year-old woman who presented simultaneously with acute inflammatory demyelinating polyneuropathy, Graves' disease, leukocytoclastic vasculitis, elevated acetylcholine antibody receptor antibodies and a mediastinal mass. Thymectomy was performed and revealed a type A thymoma and the clinical picture and paraclinical findings were consistent with a thymoma-associated multi-autoimmune syndrome (TAMA). Beside prednisolone and plasmapheresis, the patient was treated with tocilizumab and rituximab. After surgical and immunomodulatory treatment with tocilizumab and rituximab the patient's condition slowly started to improve. TAMA is associated with a spectrum of autoantibodies and immune-mediated damage to multiple organs. Even if thymectomy is crucial for long term prognosis, aggressive immunomodulation should be considered early in the disease course, especially in cases showing involvement of the peripheral and/or central nervous system.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Sveinsson O,Piehl F,Aspegren O,Hietala MAdoi
10.1016/j.jneuroim.2019.577028subject
Has Abstractpub_date
2019-11-15 00:00:00pages
577028eissn
0165-5728issn
1872-8421pii
S0165-5728(19)30339-Xjournal_volume
336pub_type
杂志文章abstract::Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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pub_type: 杂志文章
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doi:10.1016/j.jneuroim.2012.05.009
更新日期:2012-09-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(97)00018-0
更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(97)00062-3
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.06.003
更新日期:2014-08-15 00:00:00
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pub_type: 杂志文章
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