Abstract：
:Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-beta 1 levels from 230+/-21 pg/ml at baseline to 295+/-40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-beta 1 levels. Tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance. Vitamin D supplementation of MS patients for 6 months was associated with increased vitamin D status and serum TGF-beta 1.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Mahon BD,Gordon SA,Cruz J,Cosman F,Cantorna MTdoi
10.1016/s0165-5728(02)00396-xsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
128-32issue
1-2eissn
0165-5728issn
1872-8421pii
S016557280200396Xjournal_volume
134pub_type
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