Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.

abstract：:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

journal_title：Journal of neuroimmunology

authors： Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

更新日期：2000-01-03 00:00:00

abstract：:We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

journal_title：Journal of neuroimmunology

authors： Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

更新日期：2005-02-01 00:00:00

abstract：:Lewis rats sensitized against peripheral nervous system antigens can be protected against experimental allergic neuritis (EAN) by the intraperitoneal injection of silica quartz dust. Two doses of 200 mg silica given 8 and 11 days post-inoculation (dpi) protected against the development of both clinical and pathologica...

journal_title：Journal of neuroimmunology

authors： Tansey FA,Brosnan CF

更新日期：1982-11-01 00:00:00

abstract：:Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance t...

journal_title：Journal of neuroimmunology

authors： Drummond JB,Soares BS,Vieira ELM,Pedrosa W,Teixeira AL,Ribeiro-Oliveira A Jr

更新日期：2020-11-13 00:00:00

abstract：:The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

journal_title：Journal of neuroimmunology

authors： Huang DR,Pirskanen R,Matell G,Lefvert AK

更新日期：1999-02-01 00:00:00

abstract：:The kinetics and magnitude of SP receptor expression was determined for bronchoalveolar leukocyte cell subsets from BALB/c mice in the primary immune response to respiratory syncytial virus (RSV) and human parainfluenza virus-3 (PIV3) infection, and in the secondary immune response to RSV and PIV3 challenge. In both t...

journal_title：Journal of neuroimmunology

authors： Tripp RA,Barskey A,Goss L,Anderson LJ

更新日期：2002-08-01 00:00:00

abstract：:In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple sclerosis (MS) appears to be influenced by other loci. A recent study has identified a population association with an immunoglobulin heavy chain variable region polymorphism in the VH2-B5 family, with both familial and sporad...

journal_title：Journal of neuroimmunology

authors： Hashimoto LL,Walter MA,Cox DW,Ebers GC

更新日期：1993-04-01 00:00:00

abstract：:Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility C...

journal_title：Journal of neuroimmunology

authors： Sanders V,Conrad AJ,Tourtellotte WW

更新日期：1993-07-01 00:00:00

abstract：:Using the alpha(181-192) peptides of neuronal nicotinic acetylcholine receptor (nAChR) and Ala-substituted peptide analogues, amino acid residues critical for specific monoclonal antibody (mAb) binding were identified. By means of 2D nuclear magnetic resonance (2D-NMR) analysis followed by molecular modeling, it was f...

journal_title：Journal of neuroimmunology

authors： Skok M,Lykhmus E,Bobrovnik S,Tzartos S,Tsouloufis T,Vanderesse R,Coutrot F,Thong Cung M,Marraud M,Krikorian D,Sakarellos-Daitsiotis M

更新日期：2001-12-03 00:00:00

abstract：:Eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. The responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3...

journal_title：Journal of neuroimmunology

authors： Cerruti-Sola S,Kristensen F,Vandevelde M,Bichsel P,Kihm U

更新日期：1983-04-01 00:00:00

abstract：:In experimental allergic encephalomyelitis (EAE) myelin basic protein (MBP) specific T cells differ in their encephalitogenic potential. To investigate the functional diversity of human MBP specific T cell lines, we analysed their cytotoxic activity against human astrocytes and monocytes. Five out of 14 MBP specific T...

journal_title：Journal of neuroimmunology

authors： Weber F,Huber S,Aloisi F,Meinl E

更新日期：1998-08-01 00:00:00

abstract：:The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

journal_title：Journal of neuroimmunology

authors： Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

更新日期：2012-08-15 00:00:00

abstract：OBJECTIVE:Psychological stress has been implicated in the pathophysiology of both inflammatory and functional gastrointestinal (GI) diseases. The goal of this study was to address neuroendocrine modulation of cytokine production by peripheral blood cells in GI diseases. METHODS:We analyzed the in vitro effects of the ...

journal_title：Journal of neuroimmunology

authors： Lucas A,Cobelens PM,Kavelaars A,Heijnen CJ,Holtmann G,Haag S,Gerken G,Langhorst J,Dobos GJ,Schedlowski M,Elsenbruch S

更新日期：2007-01-01 00:00:00

abstract：:Gangliosides modulate various T cell effector functions through poorly defined mechanisms. To begin to understand one of their effects, the present study examined how normal brain-derived gangliosides suppress T cell proliferation using the murine T cell line, EL4, as a model. Gangliosides inhibited EL4 cell growth by...

journal_title：Journal of neuroimmunology

authors： Irani DN

更新日期：1998-07-01 00:00:00

abstract：:Peroxynitrite is formed by the reaction of nitric oxide (NO) and superoxide. Since widespread peroxynitrite activity was observed during experimental allergic encephalomyelitis (EAE), the effect of this strong lipid-peroxidizing agent on myelin integrity was examined. Incubation of myelin suspensions with the peroxyni...

journal_title：Journal of neuroimmunology

authors： van der Veen RC,Roberts LJ

更新日期：1999-03-01 00:00:00

abstract：:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

journal_title：Journal of neuroimmunology

authors： Laouini D,Kennou MF,Khoufi S,Dellagi K

更新日期：1998-11-02 00:00:00

abstract：:This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less s...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

更新日期：2013-09-15 00:00:00

abstract：:To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

journal_title：Journal of neuroimmunology

authors： Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

更新日期：2000-04-03 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythem...

journal_title：Journal of neuroimmunology

authors： Ramirez GA,Lanzani C,Bozzolo EP,Citterio L,Zagato L,Casamassima N,Canti V,Sabbadini MG,Rovere-Querini P,Manunta P,Manfredi AA

更新日期：2015-11-15 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:We examined the effect of gallium (Ga) nitrate on the development of the development of experimental autoimmune encephalomyelitis (EAE). Weekly subcutaneous injections of 10-30 mg/kg prevented clinical signs as well as histopathological changes of EAE. The optimal timing of a single injection of Ga was 6 days after in...

journal_title：Journal of neuroimmunology

authors： Whitacre C,Apseloff G,Cox K,Matkovic V,Jewell S,Gerber N

更新日期：1992-07-01 00:00:00

abstract：:HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in microglia with different phenotypes, ranging from ramified to amoebo...

journal_title：Journal of neuroimmunology

authors： Hendrickx DAE,van Eden CG,Schuurman KG,Hamann J,Huitinga I

更新日期：2017-08-15 00:00:00

abstract：:The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa li...

journal_title：Journal of neuroimmunology

authors： Hatalski CG,Hickey WF,Lipkin WI

更新日期：1998-10-01 00:00:00

abstract：:Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

journal_title：Journal of neuroimmunology

authors： Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

更新日期：1993-08-01 00:00:00

abstract：:NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

journal_title：Journal of neuroimmunology

authors： Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

更新日期：2008-05-30 00:00:00

abstract：:The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, a...

journal_title：Journal of neuroimmunology

authors： Bernardes D,Oliveira-Lima OC,Silva TV,Faraco CC,Leite HR,Juliano MA,Santos DM,Bethea JR,Brambilla R,Orian JM,Arantes RM,Carvalho-Tavares J

更新日期：2013-11-15 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:The interaction between lymphocytes and brain endothelium is a central pathogenetic event in CNS autoimmunity and, thus, represents an important focus of investigation. Chemokine binding through specific G protein-coupled receptors (GPCRs) on lymphocyte surface activates integrins and induces inside-out signaling and ...

journal_title：Journal of neuroimmunology

authors： Constantin G

更新日期：2008-07-31 00:00:00

abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

journal_title：Journal of neuroimmunology

authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

更新日期：2020-11-15 00:00:00

abstract：:Neuronal apoptosis has recently been implicated in multiple sclerosis (MS). Apoptotic cell death of neurons is induced in cultures exposed to cerebrospinal fluid (CSF) from MS patients. Since caspases are essential in the regulation of apoptosis, direct evidence was sought linking caspases to CSF-induced neuronal deat...

journal_title：Journal of neuroimmunology

authors： Cid C,Alvarez-Cermeño JC,Regidor I,Plaza J,Salinas M,Alcázar A

更新日期：2003-03-01 00:00:00