当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions.

Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions.

Abstract：

:Eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. The responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3H]thymidine incorporation and flow cytometry. All dogs developed a marked decrease of lymphocyte responsiveness toward phytohemagglutinin. Four dogs recovered rapidly from the immunosuppression and did not develop demyelination or had only mild lesions, while two others failed to recover at all and developed severe non-inflammatory demyelinating lesions. The remaining dogs exhibited a slow or partial immune recovery and had various degrees of inflammatory demyelination. Lymphocytes from 2 dogs with demyelination and 2 dogs without myelin lesions responded to myelin antigens. The findings indicate that the degree of immunosuppression in canine distemper virus infection may determine the type of demyelination and autoimmune reactions that occur during the inflammatory stage of demyelination may be epiphenomena.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Cerruti-Sola S,Kristensen F,Vandevelde M,Bichsel P,Kihm U

doi

10.1016/0165-5728(83)90013-9

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

77-90

issue

2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(83)90013-9

journal_volume

4

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.

    abstract：:Thymic tissues express transcripts encoding the alpha-3, alpha-5 and beta-4 subunits of nicotinic neuronal acetylcholine receptors (AcChRs) suggesting that neuronal AcChRs similar to those expressed in ganglia are expressed in the thymus. Transcription occurs in both isolated thymocytes and thymic epithelial cells. RT...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00120-3

    authors： Mihovilovic M,Denning S,Mai Y,Whichard LP,Patel DD,Roses AD

    更新日期：1997-11-01 00:00:00

  • Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients.

    abstract：:The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.05.004

    authors： Krestova M,Ricny J,Bartos A

    更新日期：2018-09-15 00:00:00

  • Bone marrow-derived versus parenchymal sources of inducible nitric oxide synthase in experimental autoimmune encephalomyelitis.

    abstract：:The role of nitric oxide (NO) in central nervous system (CNS) inflammation is uncertain. Whereas experimental autoimmune encephalomyelitis (EAE) is exacerbated in mice deficient in inducible nitric oxide synthase (iNOS), inhibitor studies have suggested a pro-inflammatory role for NO. These discrepancies may reflect b...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.01.020

    authors： Zehntner SP,Bourbonniere L,Hassan-Zahraee M,Tran E,Owens T

    更新日期：2004-05-01 00:00:00

  • T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice.

    abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90023-4

    authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

    更新日期：1989-05-01 00:00:00

  • The differential expression and potential roles of circular RNAs in children with anti-NMDA receptor encephalitis.

    abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577381

    authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

    更新日期：2020-11-15 00:00:00

  • Combination treatment of celecoxib and ciprofloxacin attenuates live S. aureus induced oxidative damage and inflammation in murine microglia via regulation of cytokine balance.

    abstract：:Microglial activation is the most common phenomenon in S. aureus induced brain abscesses as well as other common neurodegenerative diseases. The main objective of this study is to reduce the microglial inflammation with effective bacterial elimination. Ciprofloxacin and celecoxib were used in combination to regulate S...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.12.006

    authors： Dey R,Sultana S,Bishayi B

    更新日期：2018-03-15 00:00:00

  • Interferon beta in multiple sclerosis: relationship between sustained serum IgG levels and clinical outcome.

    abstract：:We investigated the effects of interferon beta-1a (IFN beta-1a) on specific response towards two immunodominant MBP peptides and on global production of IgG. We evaluated 54 sera from multiple sclerosis (MS) patients at baseline and 1 year after treatment. We did not observe any modification of immune response to the ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-5728(02)00204-7

    authors： Dubucquoi S,de Seze J,Lefranc D,Almeras L,Dutoit V,Prin L,Vermersch P

    更新日期：2002-08-01 00:00:00

  • A possible association between elevated serum levels of brain-specific auto-antibodies and reduced plasma levels of docosahexaenoic acid in autistic children.

    abstract：:Polyunsaturated fatty acids (PUFAs) are not only essential for energy production, but they also exhibit a range of immunomodulatory properties that progress through T cell mediated events. Autoimmunity may have a pathogenic role in a subgroup of autistic children. This study is the first to investigate the relationshi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.01.009

    authors： Mostafa GA,El-Khashab HY,Al-Ayadhi LY

    更新日期：2015-03-15 00:00:00

  • Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1 beta independent of a catecholamine-driven increase in IL-10 production.

    abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.10.016

    authors： Connor TJ,Brewer C,Kelly JP,Harkin A

    更新日期：2005-02-01 00:00:00

  • Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.

    abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00158-9

    authors： Qiu Z,Gruol DL

    更新日期：2003-06-01 00:00:00

  • Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.

    abstract：:Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00106-6

    authors： Calabresi PA,Yun SH,Allie R,Whartenby KA

    更新日期：2002-06-01 00:00:00

  • Fatty acid binding protein 4 is associated with stroke risk and severity in patients with acute ischemic stroke.

    abstract：OBJECTIVE:The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke. METHODS:All consecutive ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.07.011

    authors： Chang L,Zhang J,Liu L,Huang Z,Han Y,Zhu Y

    更新日期：2017-10-15 00:00:00

  • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

    abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.08.011

    authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

    更新日期：2010-12-15 00:00:00

  • Guillain-Barré syndrome with IgM antibody to the ganglioside GalNAc-GD1a.

    abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00451-3

    authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

    更新日期：2001-02-15 00:00:00

  • Chromosome 7q21-22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene.

    abstract：:Chromosome 7q21-22 and, in particular, the region surrounding D7S554 emerged from the recent American genome screen in multiple sclerosis (MS) as the most promising region genome-wide for harboring a disease susceptibility gene. We tested association between D7S554 and MS in 217 Sardinian trio MS families by the trans...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00023-1

    authors： Vandenbroeck K,Fiten P,Heggarty S,Goris A,Cocco E,Hawkins SA,Graham CA,Marrosu MG,Opdenakker G

    更新日期：2002-04-01 00:00:00

  • Characterization of serotonin transporter in blood lymphocytes of rats. Modulation by in vivo administration of mitogens.

    abstract：:Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.09.010

    authors： Cedeño N,Urbina M,Obregón F,Lima L

    更新日期：2005-02-01 00:00:00

  • The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.

    abstract：:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90003-9

    authors： Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

    更新日期：1989-03-01 00:00:00

  • The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

    abstract：:Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to al...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.008

    authors： Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

    更新日期：2005-10-01 00:00:00

  • Low-dosage of rituximab in Chinese patients with neuromyelitis optica spectrum disorder.

    abstract：:Rituximab has been effectively used for treating neuromyelitis optica spectrum disorder (NMOSD) for several years. However those regimens exert a heavy burden on Chinese patients. The aim of our study was to investigate an effectiveness, economic alternatives of RTX. The enrolled patients received different immunosupp...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jneuroim.2018.02.004

    authors： Lin J,Li X,Xue B,Tong Q,Chen Z,Zhu W,Li J,Xia J

    更新日期：2018-04-15 00:00:00

  • Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing-remitting multiple sclerosis compared to healthy controls.

    abstract：:CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-funct...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.09.008

    authors： Haegele KF,Stueckle CA,Malin JP,Sindern E

    更新日期：2007-02-01 00:00:00

  • Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuR.

    abstract：:In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.02.014

    authors： Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

    更新日期：2012-05-15 00:00:00

  • Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.

    abstract：:Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00011-5

    authors： Nicholas RS,Stevens S,Wing MG,Compston DA

    更新日期：2002-03-01 00:00:00

  • Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus.

    abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(84)90067-5

    authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

    更新日期：1984-09-01 00:00:00

  • Enhancement of antigen-specific T-cell reactivity on the affected side in stroke patients.

    abstract：:We have analyzed the impact of stroke with subsequent hemiparesis and sensory loss on in vivo mediated immune functions. The delayed-type hypersensitivity (DTH) reaction to purified protein derivate (PPD, tuberculin) was used as a measure of antigen-specific T-cell reactivity, and subcutaneous immunization with influe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90099-s

    authors： Tarkowski E,Ekelund P,Tarkowski A

    更新日期：1991-10-01 00:00:00

  • The significance of anti-neuronal antibodies in Alzheimer's disease.

    abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90013-8

    authors： Watts H,Kennedy PG,Thomas M

    更新日期：1981-03-01 00:00:00

  • Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies.

    abstract：:The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points followi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.03.019

    authors： Santos R,Weinstock-Guttman B,Tamaño-Blanco M,Badgett D,Zivadinov R,Justinger T,Munschauer F 3rd,Ramanathan M

    更新日期：2006-07-01 00:00:00

  • Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system.

    abstract：:The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, we...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90164-t

    authors： Cadoni A,Mancardi GL,Zaccheo D,Nocera A,Barocci S,Bianchini D,Schenone A,Capello E,Zicca A

    更新日期：1993-06-01 00:00:00

  • Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study.

    abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90116-1

    authors： Fabian RH,Hulsebosch CE

    更新日期：1989-10-01 00:00:00

  • A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease.

    abstract：:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2011.02.007

    authors： Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

    更新日期：2011-06-01 00:00:00

  • Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.

    abstract：:The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.04.002

    authors： Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G

    更新日期：2006-07-01 00:00:00