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Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

Abstract：

:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been shown to be abnormally distributed in MS tissue. To evaluate whether experimental autoimmune encephalomyelitis (EAE) provides a suitable model for this aspect of MS disease, we examined the expression and distribution of ZO-1 over the course of disease in EAE. We observed a dramatic relocalization of ZO-1 which precedes overt clinical disease and correlates with the sites of inflammatory cell accumulation. Treatment of in vitro cultures of murine brain endothelial cells with components of EAE induction provided similar findings, with relocalization of ZO-1 and increased permeability of endothelial monolayers. BBB disruption in the EAE model appears to parallel disease progression in MS, with direct effects on the cerebrovascular endothelium, making it an ideal tool for future evaluation of tight junction breakdown and repair in MS-like pathology.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

doi

10.1016/j.jneuroim.2010.08.011

subject

Has Abstract

pub_date

2010-12-15 00:00:00

pages

180-91

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00375-9

journal_volume

229

pub_type

杂志文章

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