EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

journal_title：Journal of neuroimmunology

authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

更新日期：1993-07-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

journal_title：Journal of neuroimmunology

authors： Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

更新日期：1995-02-01 00:00:00

abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

journal_title：Journal of neuroimmunology

authors： Paciotti GF,Skwerer RG,Tamarkin L

更新日期：1987-10-01 00:00:00

abstract：:IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively...

journal_title：Journal of neuroimmunology

authors： Gruol DL,Puro A,Hao C,Blakely P,Janneke E,Vo K

更新日期：2011-10-28 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

journal_title：Journal of neuroimmunology

authors： Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

更新日期：2010-12-15 00:00:00

abstract：:Studies on patients with monosymptomatic optic neuritis (ON) should give opportunities to identify features typical for early multiple sclerosis (MS). There are increased T and B cell responses to the myelin components myelin basic protein (MBP) and proteolipid protein (PLP) in both ON and MS, but there is little info...

journal_title：Journal of neuroimmunology

authors： Link J,Söderström M,Kostulas V,Olsson T,Höjeberg B,Ljungdahl A,Link H

更新日期：1994-01-01 00:00:00

abstract：:Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbet...

journal_title：Journal of neuroimmunology

authors： Lenz DC,Wolf NA,Swanborg RH

更新日期：2001-03-01 00:00:00

abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

journal_title：Journal of neuroimmunology

authors： Stevens DB,Gould KE,Swanborg RH

更新日期：1994-04-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Irazoqui FJ,Nores GA

更新日期：2000-06-26 00:00:00

abstract：:Cloned cerebrovascular endothelial cells (CVE) persistently infected with Theiler's virus (PI-CVE) have been established and characterized. The CVE were derived from strains of mice that are susceptible (SJL/J and CBA) and resistant (BALB/c) to Theiler's virus-induced demyelination (TVID). The cells were persistently ...

journal_title：Journal of neuroimmunology

authors： Sapatino BV,Petrescu AD,Rosenbaum BA,Smith R 3rd,Piedrahita JA,Welsh CJ

更新日期：1995-11-01 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00

abstract：:The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

journal_title：Journal of neuroimmunology

authors： Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

更新日期：2012-08-15 00:00:00

abstract：:We previously reported that interleukin-4 (IL-4) inhibited proliferation of a human astrocytic cell line derived from non-neoplastic adult cortex. To determine whether this effect was receptor-associated and/or limited to only non-neoplastic astrocytes, we examined IL-4 responsiveness and receptor expression in human ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Estes ML,Pettay J,Iwasaki K,Zhou P,Barnett GH

更新日期：1995-07-01 00:00:00

abstract：:Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...

journal_title：Journal of neuroimmunology

authors： Ghosh R,Dubey S,Ray BK,Purkait S,Pandit A,Benito-León J

更新日期：2020-11-15 00:00:00

abstract：:Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

journal_title：Journal of neuroimmunology

authors： Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

更新日期：2001-01-01 00:00:00

abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

journal_title：Journal of neuroimmunology

authors： Whitaker JN,McKeehan A,Freeman DW

更新日期：1994-06-01 00:00:00

abstract：:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo...

journal_title：Journal of neuroimmunology

authors： Jung S,Schluesener HJ,Toyka K,Hartung HP

更新日期：1991-12-01 00:00:00

abstract：:Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, are widely prescribed for their cholesterol-lowering properties to reduce atherogenesis and cardiovascular morbidity. Over recent years, statins have also been shown to exert pleiotropic immunomodulatory effects that might be of therapeutic benefi...

journal_title：Journal of neuroimmunology

authors： Weber MS,Youssef S,Dunn SE,Prod'homme T,Neuhaus O,Stuve O,Greenwood J,Steinman L,Zamvil SS

更新日期：2006-09-01 00:00:00

abstract：:Enzymatically derived nitric oxide (NO) has been implicated in numerous physiological and pathological processes in the brain. Whereas during development NO participates in developmental and maturation processes, excess NO production in the adult in response to inflammation, injury, or trauma participates in both cell...

journal_title：Journal of neuroimmunology

authors： Heneka MT,Feinstein DL

更新日期：2001-03-01 00:00:00

abstract：:Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...

journal_title：Journal of neuroimmunology

authors： Boontanrart M,Hall SD,Spanier JA,Hayes CE,Olson JK

更新日期：2016-03-15 00:00:00

abstract：:Neutrophil activity was elevated in the conditioned mice for the first time through an established conditioned training process. Catecholamines were proved to be important in the regulation of this conditioned innate immunity. In the study, the camphor odor (as the conditioned stimulus, CS) and poly I: C (as the uncon...

journal_title：Journal of neuroimmunology

authors： Chao HJ,Hsu YC,Yuan HP,Jiang HS,Hsueh CM

更新日期：2005-01-01 00:00:00

abstract：:After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-...

journal_title：Journal of neuroimmunology

authors： Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

更新日期：2004-01-01 00:00:00

abstract：:Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

journal_title：Journal of neuroimmunology

authors： Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

更新日期：2014-03-15 00:00:00

abstract：:We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

journal_title：Journal of neuroimmunology

authors： Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

更新日期：1991-05-01 00:00:00

abstract：:SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot of chick retinal proteins at 21 days after intravitreal injection with 5 or 10 microM/eye Glu showed decreases in 37, 42, 53 and 57 kDa proteins and increases in 35, 72 and >94 kDa proteins. These proteins were carboxylases except for the 35 and 37 kDa...

journal_title：Journal of neuroimmunology

authors： Sattayasai N,Sattayasai J,Daduang S,Chahomchuen T,Ketkaew S,Puchongkavarin H

更新日期：2003-08-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

journal_title：Journal of neuroimmunology

authors： Mendel I,Natarajan K,Ben-Nun A,Shevach EM

更新日期：2004-04-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

journal_title：Journal of neuroimmunology

authors： Conrady CD,Drevets DA,Carr DJ

更新日期：2010-03-30 00:00:00

abstract：:The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydroc...

journal_title：Journal of neuroimmunology

authors： Provencio JJ,Kivisäkk P,Tucky BH,Luciano MG,Ransohoff RM

更新日期：2005-06-01 00:00:00