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Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.

Abstract：

:After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-mediated neuroprotective mechanism (adaptive immunity) that is amenable to boosting. We postulate that the beneficial or destructive outcome of the local microglial (innate) response is determined by a well-controlled dialog between the innate and the adaptive immune players. Here, we show that spontaneous or exogenously boosted T cell-mediated neuroprotection is correlated with early activation of microglia as antigen-presenting cells. We suggest that such microglial activity, if well controlled, is a crucial step in determining the fate of the neurons in a hostile environment.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

doi

10.1016/j.jneuroim.2003.10.049

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

84-93

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803004661

journal_volume

146

pub_type

杂志文章

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