Circulating lymphocyte subpopulations in experimental allergic neuritis.

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

journal_title：Journal of neuroimmunology

authors： Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

更新日期：2018-10-15 00:00:00

abstract：:Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the...

journal_title：Journal of neuroimmunology

authors： Laman JD,van Meurs M,Schellekens MM,de Boer M,Melchers B,Massacesi L,Lassmann H,Claassen E,Hart BA

更新日期：1998-06-01 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with ...

journal_title：Journal of neuroimmunology

authors： Ogata H,Isobe N,Zhang X,Yamasaki R,Fujii T,Machida A,Morimoto N,Kaida K,Masuda T,Ando Y,Kuwahara M,Kusunoki S,Nakamura Y,Matsushita T,Kira JI

更新日期：2020-02-15 00:00:00

abstract：:Myelin basic protein (MBP)-specific SJL/J T cells were cultured in normal growth medium or growth medium supplemented with 10% culture supernatant from WEHI-3 cells, a source of interleukin-3 (IL-3), or with recombinant IL-3. T cell lines cultured with IL-3 supplementation were more encephalitogenic compared to parall...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-03-01 00:00:00

abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...

journal_title：Journal of neuroimmunology

authors： Brini E,Ruffini F,Bergami A,Brambilla E,Dati G,Greco B,Cirillo R,Proudfoot AE,Comi G,Furlan R,Zaratin P,Martino G

更新日期：2009-04-30 00:00:00

abstract：:In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

journal_title：Journal of neuroimmunology

authors： Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

更新日期：2012-05-15 00:00:00

abstract：:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased aft...

journal_title：Journal of neuroimmunology

authors： Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE

更新日期：1991-04-01 00:00:00

abstract：:Demyelination, a pathological hallmark of multiple sclerosis, may be a necessary but not a sufficient condition for motor dysfunction associated with this disease. We favor a neurodegenerative model of multiple sclerosis and suggest that demyelination creates a permissive environment wherein the denuded axon becomes s...

journal_title：Journal of neuroimmunology

authors： Howe CL,Ure D,Adelson JD,LaFrance-Corey R,Johnson A,Rodriguez M

更新日期：2007-08-01 00:00:00

abstract：:We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination. In this study we tested the hypothesis that loss of astrocytic gap junction proteins leads to exacerbation of the primary demyelinating diseases, using experimental autoimmune encepha...

journal_title：Journal of neuroimmunology

authors： Lutz SE,Raine CS,Brosnan CF

更新日期：2012-04-01 00:00:00

abstract：:15% of myasthenia gravis (MG) patients do not have antibodies against the acetylcholine receptor (AChR). Some of these "seronegative" MG patients have antibodies against muscle specific kinase (MuSK), and many have a non-IgG factor that acutely inhibits AChR function in a muscle-like cell line, CN21. Here we show, usi...

journal_title：Journal of neuroimmunology

authors： Spreadbury I,Kishore U,Beeson D,Vincent A

更新日期：2005-05-01 00:00:00

abstract：:The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methylation of the SHP-1 p...

journal_title：Journal of neuroimmunology

authors： Kumagai C,Kalman B,Middleton FA,Vyshkina T,Massa PT

更新日期：2012-05-15 00:00:00

abstract：:Sp3 belongs to a large family of transcription factors that bind GC/T box elements. We have previously demonstrated the deficient expression of Sp3 in peripheral blood mononuclear cells (PBMC) from most patients with multiple sclerosis (MS). In the current study, the Sp3 gene was assigned to chromosome 7 by using soma...

journal_title：Journal of neuroimmunology

authors： Grekova MC,Scherer SW,Trabb J,Richert JR

更新日期：2000-07-01 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points followi...

journal_title：Journal of neuroimmunology

authors： Santos R,Weinstock-Guttman B,Tamaño-Blanco M,Badgett D,Zivadinov R,Justinger T,Munschauer F 3rd,Ramanathan M

更新日期：2006-07-01 00:00:00

abstract：:In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for as...

journal_title：Journal of neuroimmunology

authors： Eraksoy M,Hensiek A,Kurtuncu M,Akman-Demir G,Kilinc M,Gedizlioglu M,Petek-Balci B,Anlar O,Kutlu C,Saruhan-Direskeneli G,Idrisoglu HA,Setakis E,Compston A,Sawcer S,Turkish Multiple Sclerosis Genetics Study Group.

更新日期：2003-10-01 00:00:00

abstract：:Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, follow...

journal_title：Journal of neuroimmunology

authors： Nischwitz S,Wolf C,Andlauer TF,Czamara D,Zettl UK,Rieckmann P,Buck D,Ising M,Bettecken T,Mueller-Myhsok B,Weber F

更新日期：2015-02-15 00:00:00

abstract：:Autotaxin (ATX) is an enzyme producing lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC) and it is up-regulated in inflammatory conditions such as various cancers, arthritis and multiple sclerosis (MS). Numerous studies have shown that the LPA signaling gives rise to angiogenesis, mitosis, cell prolifera...

journal_title：Journal of neuroimmunology

authors： Zahednasab H,Balood M,Harirchian MH,Mesbah-Namin SA,Rahimian N,Siroos B

更新日期：2014-08-15 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00

abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

journal_title：Journal of neuroimmunology

authors： Hellström-Lindahl E,Nordberg A

更新日期：1996-08-01 00:00:00

abstract：:The proportions of CD2+, CD4+ and CD8+ lymphocytes were determined with the 3-layer indirect immunoperoxidase technique in the cerebrospinal fluid (CSF) of 31 patients with myasthenia gravis (MG) and 21 control subjects without autoimmune or central nervous system (CNS) diseases. None of the MG patients were using imm...

journal_title：Journal of neuroimmunology

authors： Müller KM,Taskinen E,Iivanainen M

更新日期：1990-12-01 00:00:00

abstract：:The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. How...

journal_title：Journal of neuroimmunology

authors： Flood L,Korol SV,Ekselius L,Birnir B,Jin Z

更新日期：2019-12-15 00:00:00

abstract：:Lactogen-dependent Nb2 cell lines have been widely employed to investigate signaling mechanisms coupled to prolactin receptor (PRLR)-stimulated transcription of hormone-responsive genes. We previously reported that PRL rapidly induced expression of the immediate-early protooncogene, pim-1. In the present report, we de...

journal_title：Journal of neuroimmunology

authors： Buckley AR

更新日期：2000-09-01 00:00:00

abstract：:We previously reported that interleukin-4 (IL-4) inhibited proliferation of a human astrocytic cell line derived from non-neoplastic adult cortex. To determine whether this effect was receptor-associated and/or limited to only non-neoplastic astrocytes, we examined IL-4 responsiveness and receptor expression in human ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Estes ML,Pettay J,Iwasaki K,Zhou P,Barnett GH

更新日期：1995-07-01 00:00:00

abstract：:After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-...

journal_title：Journal of neuroimmunology

authors： Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

更新日期：2004-01-01 00:00:00

abstract：:Little is known regarding protein responses to syphilis infection in cerebrospinal fluid (CSF) of patients presenting with neurosyphilis. Protein and antibody arrays offer a new opportunity to gain insights into global protein expression profiles in these patients. Here we obtained CSF samples from 46 syphilis patient...

journal_title：Journal of neuroimmunology

authors： Lu P,Zheng DC,Fang C,Huang JM,Ke WJ,Wang LY,Zeng WY,Zheng HP,Yang B

更新日期：2016-04-15 00:00:00

abstract：:The Th1-like cytokines, interleukin 2 (IL-2), interferon gamma (IFN-gamma), and lymphotoxin alpha (LT-alpha) have been implicated in the immunopathogenesis of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), an animal model of immune mediated demyelination. These cytokines have been associate...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Fields NS,Farnon EC,Frank JA,Bash CN,Kawanashi T,Maloni H,Jacobson S,McFarland HF

更新日期：1998-05-15 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...

journal_title：Journal of neuroimmunology

authors： Lin L,Hungs M,Mignot E

更新日期：2001-07-02 00:00:00