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Localization of the human SP3 gene to chromosome 7p14-p15.2. The lack of expression in multiple sclerosis does not reflect abnormal gene organization.

Abstract：

:Sp3 belongs to a large family of transcription factors that bind GC/T box elements. We have previously demonstrated the deficient expression of Sp3 in peripheral blood mononuclear cells (PBMC) from most patients with multiple sclerosis (MS). In the current study, the Sp3 gene was assigned to chromosome 7 by using somatic cell hybrid mapping and analysis of a chromosome 7-specific cosmid library. The position of Sp3 was refined to 7p14-p15.2 by fluorescence in situ hybridization (FISH). Southern blot and polymerase chain reaction analysis of genomic DNA failed to demonstrate a detectable difference between MS and control PBMC.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Grekova MC,Scherer SW,Trabb J,Richert JR

doi

10.1016/s0165-5728(99)00264-7

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

214-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572899002647

journal_volume

106

pub_type

杂志文章

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