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Prognostic value of oligoclonal IgG bands in Japanese clinically isolated syndrome converting to clinically definite multiple sclerosis.

Abstract：

:We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barkhof criteria at baseline. 60.0% of CIS patients with positive OCBs and 9.5% of those with negative OCBs developed CDMS during 60.6months. Japanese CIS patients with positive OCBs have an equivalent risk of developing CDMS. A hypothesis that Japanese CIS patients may have substantially less OCBs positivity, MRI lesions, and conversion ratio than Caucasians, should be further tested.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kinoshita M,Daifu M,Tanaka K,Tanaka M

doi

10.1016/j.jneuroim.2017.03.010

subject

Has Abstract

pub_date

2017-06-15 00:00:00

pages

1-6

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30344-7

journal_volume

307

pub_type

杂志文章

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