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G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: a possible mechanism for exacerbation of multiple sclerosis.

Abstract：

:Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T-cell properties, which can promote CNS inflammation in MS. We show that G-CSF enhances MS autoreactive T cell line adhesion to the ECM proteins collagen IV and fibronectin as effectively as the proinflammatory IFNgamma and TNFalpha, known to exacerbate MS symptoms. We propose a link between clinical worsening of MS symptoms induced by G-CSF and the hyperstimulation of T cell adhesion to ECM elicited by G-CSF.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Snir O,Lavie G,Achiron A,Bank I,Ben-Aharon T,Sredni B,Cohen IR,Mandel M

doi

10.1016/j.jneuroim.2005.11.012

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

145-55

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00496-0

journal_volume

172

pub_type

杂志文章

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