Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.

abstract：:IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12R beta 2) expression was investigated in experimental autoimmune uveitis (EAU) susc...

journal_title：Journal of neuroimmunology

authors： Wu Y,Lin Y,Hou W,Wang Y,Sun B

更新日期：2003-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

journal_title：Journal of neuroimmunology

authors： Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

更新日期：2018-05-15 00:00:00

abstract：:Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the c...

journal_title：Journal of neuroimmunology

authors： Dörries R,Watanabe R,Wege H,ter Meulen V

更新日期：1987-04-01 00:00:00

abstract：:Alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that can inhibit a broad range of inflammatory mediators known to be involved in the pathophysiology of bacterial meningitis. We evaluated the effect of alpha-MSH in a rat model of pneumococcal meningitis. Rats were intraci...

journal_title：Journal of neuroimmunology

authors： Kastenbauer S,Koedel U,Brzoska T,Luger TA,Pfister HW

更新日期：2001-05-01 00:00:00

abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

journal_title：Journal of neuroimmunology

authors： Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

更新日期：2010-05-01 00:00:00

abstract：:Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the cur...

journal_title：Journal of neuroimmunology

authors： Benveniste EN,Sparacio SM,Norris JG,Grenett HE,Fuller GM

更新日期：1990-12-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

journal_title：Journal of neuroimmunology

authors： Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

更新日期：1986-03-01 00:00:00

abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

journal_title：Journal of neuroimmunology

authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

更新日期：1982-06-01 00:00:00

abstract：:Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central...

journal_title：Journal of neuroimmunology

authors： Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

更新日期：1993-11-01 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00

abstract：:CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leuko...

journal_title：Journal of neuroimmunology

authors： Thelen M,Thelen S

更新日期：2008-07-31 00:00:00

abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

journal_title：Journal of neuroimmunology

authors： Watts H,Kennedy PG,Thomas M

更新日期：1981-03-01 00:00:00

abstract：:In the century and a half since multiple sclerosis (MS) was first recognized, the pathology of the condition has been defined with increasing detail. From the recognition and definition of MS as a clinical phenomenon, studies of the diseased brain tissue have progressed in a manner dependent on the science of the time...

journal_title：Journal of neuroimmunology

authors： Hickey WF

更新日期：1999-07-01 00:00:00

abstract：:Transmitters and cotransmitters of the sympathetic nervous system are involved in the regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli lead to the release of these molecules in immune organs. In this study, we investigated whether local ischemia can cause the parallel re...

journal_title：Journal of neuroimmunology

authors： Sperlágh B,Dóda M,Baranyi M,Haskó G

更新日期：2000-11-01 00:00:00

abstract：:Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T...

journal_title：Journal of neuroimmunology

authors： Snir O,Lavie G,Achiron A,Bank I,Ben-Aharon T,Sredni B,Cohen IR,Mandel M

更新日期：2006-03-01 00:00:00

abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

journal_title：Journal of neuroimmunology

authors： Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

更新日期：1990-09-01 00:00:00

abstract：:This study investigates the role of beta-adrenergic receptors in the immunomodulatory effects of a conditioned aversive stimulus (CS). A CS is an environmental event that is not inherently aversive, but acquires aversive properties through pairings with a stimulus such as electric shock. This study evaluated the effec...

journal_title：Journal of neuroimmunology

authors： Luecken LJ,Lysle DT

更新日期：1992-06-01 00:00:00

abstract：:Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and ...

journal_title：Journal of neuroimmunology

authors： Mantegazza R,Bernasconi P,Baggi F,Spreafico R,Ragona F,Antozzi C,Bernardi G,Granata T

更新日期：2002-10-01 00:00:00

abstract：:The capacity of three different human glioblastoma cell lines to activate human T cells was analysed by measuring major histocompatibility complex (MHC) antigen expression, monokine secretion and lectin, mAb OKT3 and antigen-driven T cell proliferation. All glioblastoma cells tested were able to induce PHA and concana...

journal_title：Journal of neuroimmunology

authors： Däubener W,Zennati SS,Wernet P,Bilzer T,Fischer HG,Hadding U

更新日期：1992-11-01 00:00:00

abstract：:Acute infusions of the formylated chemotactic peptide formyl-methionyl-leucyl-phenylalanine-lysine (FMLPL) or enkephalin analogue (Sandoz peptide) were made to the lateral cerebral ventricle of adult male rats to examine potential cellular responses within the central nervous system (CNS). Ependymal regions lining the...

journal_title：Journal of neuroimmunology

authors： Saland LC,Van Epps DE,Maez D,Gutierrez L,Samora A

更新日期：1988-06-01 00:00:00

abstract：:The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. How...

journal_title：Journal of neuroimmunology

authors： Flood L,Korol SV,Ekselius L,Birnir B,Jin Z

更新日期：2019-12-15 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately...

journal_title：Journal of neuroimmunology

authors： Dijkstra CD,De Groot CJ,Huitinga I

更新日期：1992-10-01 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS. Stimulation of endothelial ...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Noori MA,Ciardi M,Cirelli A,Thompson EJ

更新日期：1993-03-01 00:00:00

abstract：:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lun...

journal_title：Journal of neuroimmunology

authors： Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

更新日期：2015-09-15 00:00:00

abstract：:The localization of dopamine stores and the expression and localization of vesicular monoamine transporter (VMAT) type-1 and 2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat thymus and spleen by immunohistochemical, immunochemical techniques and by RT-PCR. In the thymus dopamine immunor...

journal_title：Journal of neuroimmunology

authors： Mignini F,Tomassoni D,Traini E,Amenta F

更新日期：2009-01-03 00:00:00

abstract：:Peroxynitrite is formed by the reaction of nitric oxide (NO) and superoxide. Since widespread peroxynitrite activity was observed during experimental allergic encephalomyelitis (EAE), the effect of this strong lipid-peroxidizing agent on myelin integrity was examined. Incubation of myelin suspensions with the peroxyni...

journal_title：Journal of neuroimmunology

authors： van der Veen RC,Roberts LJ

更新日期：1999-03-01 00:00:00

abstract：:This study explores nasal administration of myelin basic protein (MBP) as a potential means of inducing tolerance to relapsing experimental autoimmune encephalomyelitis (PR-EAE), an experimental multiple sclerosis (MS) model that was induced in DA rats by immunization with rat spinal cord homogenate and incomplete Fre...

journal_title：Journal of neuroimmunology

authors： Bai XF,Shi FD,Xiao BG,Li HL,van der Meide PH,Link H

更新日期：1997-12-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

journal_title：Journal of neuroimmunology

authors： Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

更新日期：2004-04-01 00:00:00

abstract：:Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbet...

journal_title：Journal of neuroimmunology

authors： Lenz DC,Wolf NA,Swanborg RH

更新日期：2001-03-01 00:00:00