当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Induction and regulation of interleukin-6 gene expression in rat astrocytes.

Induction and regulation of interleukin-6 gene expression in rat astrocytes.

Abstract：

:Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the current study, we show that either interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) exert a strong inducing signal for IL-6 in primary rat astrocytes. When the two cytokines are added together the response is synergistic, suggesting that each cytokine may induce IL-6 gene expression by different pathways. Interferon-gamma (IFN-gamma) does not affect IL-6 expression although if it is added in conjunction with IL-1 beta, an augmented induction of IL-6 occurs. In addition to the cytokines, bacterial lipopolysaccharide (LPS) and the calcium ionophore, A23187, induce IL-6 expression. IL-6 expression can be blocked by the glucocorticoid analogue, dexamethasone. IL-6 induction by LPS/Ca2+ ionophore is more sensitive to the suppressive effects of dexamethasone than is IL-6 induction by TNF-alpha/IL-1 beta. Cycloheximide (CHX), an inhibitor of protein synthesis, markedly increased levels of IL-6 mRNA in both unstimulated and stimulated astrocytes, indicating that ongoing protein synthesis is not required for astrocyte IL-6 gene expression. We propose that astrocyte-produced IL-6 may have a role in augmenting intracerebral immune responses in neurological diseases such as multiple sclerosis (MS), AIDS dementia complex (ADC), and viral infections. These diseases are characterized by infiltration of lymphoid and mononuclear cells into the central nervous system (CNS), and intrathecal production of immunoglobulins. IL-6 may act to promote terminal differentiation of B cells in the CNS, leading to immunoglobulin synthesis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Benveniste EN,Sparacio SM,Norris JG,Grenett HE,Fuller GM

doi

10.1016/0165-5728(90)90104-u

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

201-12

issue

2-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(90)90104-U

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Lymphocyte proliferative response to glial cells in SJL/J mice immunized with rat whole spinal cord and rat myelin basic protein.

    abstract：:Lymph node cells (LNC) from SJL/J mice immunized with either rat whole spinal cord (WSC) homogenate or rat myelin basic protein (MBP) in the presence of complete Freund's adjuvant were assayed for their in vitro proliferative response to MBP and whole or sonicated purified oligodendrocytes (OD), and astrocytes. WSC-im...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90162-8

    authors： Jewtoukoff V,Bach MA

    更新日期：1989-01-01 00:00:00

  • Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

    abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.02.014

    authors： Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

    更新日期：2010-05-01 00:00:00

  • Statins in the treatment of central nervous system autoimmune disease.

    abstract：:Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, are widely prescribed for their cholesterol-lowering properties to reduce atherogenesis and cardiovascular morbidity. Over recent years, statins have also been shown to exert pleiotropic immunomodulatory effects that might be of therapeutic benefi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2006.06.006

    authors： Weber MS,Youssef S,Dunn SE,Prod'homme T,Neuhaus O,Stuve O,Greenwood J,Steinman L,Zamvil SS

    更新日期：2006-09-01 00:00:00

  • Body mass index influence interferon-beta treatment response in multiple sclerosis.

    abstract：:Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) du...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2015.09.008

    authors： Kvistad SS,Myhr KM,Holmøy T,Šaltytė Benth J,Wergeland S,Beiske AG,Bjerve KS,Hovdal H,Lilleås F,Midgard R,Pedersen T,Bakke SJ,Michelsen AE,Aukrust P,Ueland T,Sagen JV,Torkildsen Ø

    更新日期：2015-11-15 00:00:00

  • Effects of dexamethasone on microglial activation in vivo: selective downregulation of major histocompatibility complex class II expression in regenerating facial nucleus.

    abstract：:Following axotomy of the facial nerve microglial cells in the facial nucleus become activated, proliferate, and newly express class I and class II major histocompatibility complex (MHC) antigens. Dexamethasone treatment, starting 2 days prior to axotomy at 1 mg/kg/day, selectively inhibited axotomy-induced MHC class I...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90119-r

    authors： Kiefer R,Kreutzberg GW

    更新日期：1991-11-01 00:00:00

  • Protection against experimental allergic neuritis with silica quartz dust.

    abstract：:Lewis rats sensitized against peripheral nervous system antigens can be protected against experimental allergic neuritis (EAN) by the intraperitoneal injection of silica quartz dust. Two doses of 200 mg silica given 8 and 11 days post-inoculation (dpi) protected against the development of both clinical and pathologica...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(82)90020-0

    authors： Tansey FA,Brosnan CF

    更新日期：1982-11-01 00:00:00

  • Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis.

    abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90131-7

    authors： Stevens DB,Gould KE,Swanborg RH

    更新日期：1994-04-01 00:00:00

  • TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.

    abstract：:Microglial inflammation plays a pivotal role in the pathogenesis of S. aureus induced brain abscesses. The objective of this study was to regulate microglial activation by the combinatorial treatment of ciprofloxacin either with dexamethasone or celecoxib via targeting M1 and M2 polarization. The antibiotic-immunomodu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577262

    authors： Dey R,Bishayi B

    更新日期：2020-07-15 00:00:00

  • Glial transforming growth factor (TGF)-beta isotypes in multiple sclerosis: differential glial expression of TGF-beta 1, 2 and 3 isotypes in multiple sclerosis.

    abstract：:We studied glial transforming growth factor (TGF)-beta isotype expression in 14 cases of multiple sclerosis. Acute active lesions exhibited selective TGF-beta 2 immunoreactivity of lesion encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions expressed all three isotypes. Chr...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00135-x

    authors： Peress NS,Perillo E,Seidman RJ

    更新日期：1996-12-01 00:00:00

  • A monoclonal antibody recognizing subpopulations of neurones in mouse brain.

    abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90034-6

    authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

    更新日期：1983-06-01 00:00:00

  • No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.

    abstract：:Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.10.005

    authors： Sulonen AM,Kallio SP,Ellonen P,Suvela M,Elovaara I,Koivisto K,Pirttilä T,Reunanen M,Tienari PJ,Palotie A,Peltonen L,Saarela J

    更新日期：2009-01-03 00:00:00

  • Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes.

    abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.012

    authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

    更新日期：2005-10-01 00:00:00

  • T lymphocyte subset abnormalities in peripheral blood from patients with the Guillain-Barré syndrome.

    abstract：:T lymphocytes are probably of pathogenic importance in many autoimmune diseases. Recently, deviations of circulating T-helper (CD4+) subpopulations have been noticed. Blood samples from 12 patients with Guillain-Barré syndrome (GBS) were studied with flow cytometry during their disease course to define circulating T c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90032-9

    authors： Dahle C,Vrethem M,Ernerudh J

    更新日期：1994-09-01 00:00:00

  • The significance of anti-neuronal antibodies in Alzheimer's disease.

    abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90013-8

    authors： Watts H,Kennedy PG,Thomas M

    更新日期：1981-03-01 00:00:00

  • Isolated opsoclonus heralding neuromyelitis optica spectrum disorder.

    abstract：:Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577394

    authors： Ghosh R,Dubey S,Ray BK,Purkait S,Pandit A,Benito-León J

    更新日期：2020-11-15 00:00:00

  • The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)2D3.

    abstract：:Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role in central and peripheral tolerance. DCs not only drive T cell priming and differentiation via playing antigen presentation fun...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.577079

    authors： Cao Q,Zheng C,Xie Z,Liu L,Zhu J,Jin T

    更新日期：2020-01-15 00:00:00

  • Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis.

    abstract：:Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90075-1

    authors： Lyman WD,Sonett JR,Brosnan CF,Elkin R,Bornstein MB

    更新日期：1989-06-01 00:00:00

  • Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

    abstract：:Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscle's proteomi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.05.008

    authors： Gomez AM,Vanheel A,Losen M,Molenaar PC,De Baets MH,Noben JP,Hellings N,Martinez-Martinez P

    更新日期：2013-08-15 00:00:00

  • Monoclonal antibodies to central nervous system antigens.

    abstract：:Thirty monoclonal antibodies produced by mouse hybrid myelomas which react with antigens in hamster or mouse nervous system tissues were derived. Using these antibodies as probes with indirect immunofluorescence and immunoperoxidase techniques, we can selectively identify by morphological criteria many of the structur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90019-9

    authors： Franko MC,Masters CL,Gibbs CJ Jr,Gajdusek DC

    更新日期：1981-12-01 00:00:00

  • An investigation into the association between HLA-G 14 bp insertion/deletion polymorphism and multiple sclerosis susceptibility.

    abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.11.019

    authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

    更新日期：2016-01-15 00:00:00

  • Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination.

    abstract：:To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myeli...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00060-5

    authors： Stinissen P,Zhang J,Vandevyver C,Hermans G,Raus J

    更新日期：1998-07-01 00:00:00

  • Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice.

    abstract：:To characterize behavioral and physiological alterations induced by viral respiratory infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days after intranasal inoculation with influenza virus. Both strains developed hypothermia, decrease locomotor activity, and decreased delta-wave am...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)00193-r

    authors： Toth LA,Rehg JE,Webster RG

    更新日期：1995-04-01 00:00:00

  • Autoantibodies against pituitary peptides in sera from patients with multiple sclerosis.

    abstract：:Autoantibodies against pituitary peptides were demonstrated in sera from multiple sclerosis (MS) patients. Ten patients with lupus erythematosus disseminatus (SLE) and 97 healthy blood donors served as controls. The sera were used as primary antibodies in the indirect immuno-enzyme cytochemical (IEC) method, with fixe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90007-3

    authors： Hansen BL,Hansen GN,Hagen C,Brodersen P

    更新日期：1983-10-01 00:00:00

  • An Epstein Barr virus-related cross reactive autoimmune response in multiple sclerosis in Norway.

    abstract：:In studies of patients in Norway with multiple sclerosis (MS), we have found cross reactive autoantibodies related to the Epstein Barr virus nuclear antigen-1 (EBNA-1). The MS patients had elevated IgG antibody to EBNA-1, as measured by reactivity with a synthetic glycine/alanine peptide, P62, which represents the gly...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(96)00069-0

    authors： Vaughan JH,Riise T,Rhodes GH,Nguyen MD,Barrett-Connor E,Nyland H

    更新日期：1996-09-01 00:00:00

  • Therapeutic effects of anti-Delta1 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease.

    abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.08.003

    authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

    更新日期：2012-11-15 00:00:00

  • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant.

    abstract：:Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and impaired function. Harmful mediators are accumulating in the brain after injury and recently, the role of cytokines in the pathophysiology of brain injury has been suggested. We have developed an experimental model for closed ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-5728(96)00181-6

    authors： Shohami E,Gallily R,Mechoulam R,Bass R,Ben-Hur T

    更新日期：1997-02-01 00:00:00

  • Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) is emerging as an important modulator of the function of the central nervous system. In the present study, we investigated a role of endogenous TNF-alpha in cognitive and emotional function using mice with targeted deletions of the TNF-alpha gene. TNF-alpha-(-/-) mice showed nor...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00375-1

    authors： Yamada K,Iida R,Miyamoto Y,Saito K,Sekikawa K,Seishima M,Nabeshima T

    更新日期：2000-11-01 00:00:00

  • Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients.

    abstract：BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.04.008

    authors： Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

    更新日期：2007-07-01 00:00:00

  • Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.

    abstract：:Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00106-6

    authors： Calabresi PA,Yun SH,Allie R,Whartenby KA

    更新日期：2002-06-01 00:00:00

  • Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis.

    abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.10.004

    authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

    更新日期：2013-12-15 00:00:00