当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

Abstract：

:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals and observed extensive alternative splicing of both genes with marked differences in proportional transcript expression levels. We report here for the first time that the IL-7 transcript, lacking exon 4, and not the full length IL-7 represents the dominant IL-7 RNA transcript in human PBMCs and a novel IL-7R splice variant lacking exons 5, 6 and 7.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

doi

10.1016/j.jneuroim.2010.02.014

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

82-6

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00063-9

journal_volume

222

pub_type

杂志文章

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