Primary and secondary involvement of the CNS in HIV infection.

Abstract:

:The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurologic diseases, although in a given patient rare and sometimes multiple complications have to be considered. The clinical features of acquired immunodeficiency syndrome (AIDS) encephalopathy and CNS toxoplasmosis that represent the major primary and secondary neurologic manifestations of AIDS are discussed in detail.

journal_name

J Neuroimmunol

authors

Fischer PA,Enzensberger W

doi

10.1016/0165-5728(88)90143-9

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

127-31

issue

2-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(88)90143-9

journal_volume

20

pub_type

杂志文章,评审
  • Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists.

    abstract::Immunological responses to protect against excessive inflammation can be regulated by the central nervous system through the cholinergic anti-inflammatory pathway wherein acetylcholine released from vagus nerves can inhibit inflammatory cytokines. Although a role for the α7 nicotinic acetylcholine receptor (α7 nAChR) ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2011.08.007

    authors: Li J,Mathieu SL,Harris R,Ji J,Anderson DJ,Malysz J,Bunnelle WH,Waring JF,Marsh KC,Murtaza A,Olson LM,Gopalakrishnan M

    更新日期:2011-10-28 00:00:00

  • Beta-endorphin alters a viral induced central nervous system disease in normal mice but not in nude mice.

    abstract::A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(89)90097-0

    authors: Doll SC,Johnson TC

    更新日期:1989-09-01 00:00:00

  • Immunocytochemical characterisation of cell cultures grown from dissociated 1-2-day post-natal rat cerebral tissue. A developmental study.

    abstract::A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(84)80002-8

    authors: Walker AG,Chapman J,Bruce CB,Rumsby MG

    更新日期:1984-11-01 00:00:00

  • How cytokines can influence the brain: a role for chemokines?

    abstract::Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence th...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jneuroim.2008.04.009

    authors: Guyon A,Massa F,Rovère C,Nahon JL

    更新日期:2008-07-31 00:00:00

  • T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis.

    abstract::Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP reporter mice. Effecto...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2016.04.010

    authors: Kulcsar KA,Griffin DE

    更新日期:2016-06-15 00:00:00

  • Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.

    abstract::To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00242-8

    authors: Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

    更新日期:2000-04-03 00:00:00

  • Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy.

    abstract::To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2019.577139

    authors: Ogata H,Isobe N,Zhang X,Yamasaki R,Fujii T,Machida A,Morimoto N,Kaida K,Masuda T,Ando Y,Kuwahara M,Kusunoki S,Nakamura Y,Matsushita T,Kira JI

    更新日期:2020-02-15 00:00:00

  • Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway.

    abstract::The microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) or Rho/Rho kinase (ROCK) are both involved in the development of non-specific inflammation. However, there are few...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2017.02.010

    authors: Chen J,Sun Z,Jin M,Tu Y,Wang S,Yang X,Chen Q,Zhang X,Han Y,Pi R

    更新日期:2017-04-15 00:00:00

  • Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes.

    abstract::DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2005.06.012

    authors: Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

    更新日期:2005-10-01 00:00:00

  • Immune response in lung cancer mouse model mimics human anti-Hu reactivity.

    abstract::Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2009.08.014

    authors: Kazarian M,Calbo J,Proost N,Carpenter CL,Berns A,Laird-Offringa IA

    更新日期:2009-12-10 00:00:00

  • Immune reactive C3d on the surface of myelin sheaths in neuropathy.

    abstract::Immunofluorescence studies of sural nerve demonstrated immune reactive C3d and IgM on the surface of myelin sheaths in seven patients with neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M-protein. Similar deposits of C3d and sometimes IgM were found in four of six patients with acute or chronic inflam...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(88)90101-4

    authors: Hays AP,Lee SS,Latov N

    更新日期:1988-06-01 00:00:00

  • Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis.

    abstract::TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2003.12.014

    authors: Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

    更新日期:2004-04-01 00:00:00

  • On classification of post-mortem multiple sclerosis plaques for neuroscientists.

    abstract::Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility C...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(93)90251-s

    authors: Sanders V,Conrad AJ,Tourtellotte WW

    更新日期:1993-07-01 00:00:00

  • Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

    abstract::Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2012.12.003

    authors: Unoda K,Doi Y,Nakajima H,Yamane K,Hosokawa T,Ishida S,Kimura F,Hanafusa T

    更新日期:2013-03-15 00:00:00

  • Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes.

    abstract::Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(85)80018-7

    authors: Hohlfeld R,Toyka KV

    更新日期:1985-08-01 00:00:00

  • Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.

    abstract::Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx int...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(00)00183-1

    authors: Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

    更新日期:2000-06-01 00:00:00

  • Thymic myoid cells express high levels of muscle genes.

    abstract::To explore the possible contribution of thymic myoid cells in tolerance induction mechanisms, we quantified by real-time RT-PCR, the expression of 12 muscle genes (the five subunits of acetylcholine receptor, Musk, rapsyn, utrophin, ErbB2, ErbB3, troponin T, and MCK) in a human thymic myoid cell line (MITC), compared ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2003.11.013

    authors: Mesnard-Rouiller L,Bismuth J,Wakkach A,Poëa-Guyon S,Berrih-Aknin S

    更新日期:2004-03-01 00:00:00

  • T lymphocyte subset abnormalities in peripheral blood from patients with the Guillain-Barré syndrome.

    abstract::T lymphocytes are probably of pathogenic importance in many autoimmune diseases. Recently, deviations of circulating T-helper (CD4+) subpopulations have been noticed. Blood samples from 12 patients with Guillain-Barré syndrome (GBS) were studied with flow cytometry during their disease course to define circulating T c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)90032-9

    authors: Dahle C,Vrethem M,Ernerudh J

    更新日期:1994-09-01 00:00:00

  • Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies.

    abstract::The two chemokines, monocyte chemoattractant protein (MCP)-1 and gamma-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and from 40 controls. The latter co...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0165-5728(01)00261-2

    authors: Franciotta D,Martino G,Zardini E,Furlan R,Bergamaschi R,Andreoni L,Cosi V

    更新日期:2001-04-02 00:00:00

  • Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population.

    abstract::Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopme...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.09.019

    authors: Kapelski P,Skibinska M,Maciukiewicz M,Pawlak J,Permoda-Osip A,Twarowska-Hauser J

    更新日期:2015-08-15 00:00:00

  • Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS.

    abstract::An altered peptide ligand (analog) of the encephalitogenic epitope of proteolipid protein residues 139-151 (p139-151) in which residues 144 and 147 are substituted with leucine and arginine, respectively (LR), protects from clinical but not histological experimental allergic encephalomyelitis (EAE). To understand in s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(97)00138-0

    authors: Santambrogio L,Lees MB,Sobel RA

    更新日期:1998-01-01 00:00:00

  • Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis.

    abstract::Axonal injury is the major cause of disability in patients with multiple sclerosis (MS), but the mechanisms leading to axonal damage are poorly understood. Oligoclonal IgM against lipids predicts an aggressive disease course in MS; however, the antigen that elicits the immune response has not yet been identified. We s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2012.03.013

    authors: Beltrán E,Hernández A,Lafuente EM,Coret F,Simó-Castelló M,Boscá I,Pérez-Miralles FC,Burgal M,Casanova B

    更新日期:2012-06-15 00:00:00

  • Parental genes do not codominantly confer susceptibility to experimental autoimmune encephalomyelitis in F1 rats.

    abstract::Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbet...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00244-2

    authors: Lenz DC,Wolf NA,Swanborg RH

    更新日期:2001-03-01 00:00:00

  • TRPC6 gene variants and neuropsychiatric lupus.

    abstract::Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythem...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2015.08.015

    authors: Ramirez GA,Lanzani C,Bozzolo EP,Citterio L,Zagato L,Casamassima N,Canti V,Sabbadini MG,Rovere-Querini P,Manunta P,Manfredi AA

    更新日期:2015-11-15 00:00:00

  • Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.

    abstract::Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.04.011

    authors: Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

    更新日期:2006-07-01 00:00:00

  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.

    abstract::Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encep...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.10.006

    authors: Carter LL,Leach MW,Azoitei ML,Cui J,Pelker JW,Jussif J,Benoit S,Ireland G,Luxenberg D,Askew GR,Milarski KL,Groves C,Brown T,Carito BA,Percival K,Carreno BM,Collins M,Marusic S

    更新日期:2007-01-01 00:00:00

  • Chronic restraint stress modulates expression of genes in murine spleen.

    abstract::Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.05.004

    authors: Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

    更新日期:2006-08-01 00:00:00

  • Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression.

    abstract::Experimental autoimmune encephalomyelitis (EAE) is a T helper 1 (Th1) cell mediated demyelinating disease and the principal animal model for multiple sclerosis. Spinal cords from SJL mice primed with proteolipid protein peptide 139-151 (pPLP) expressed the chemokines RANTES, MCP-1, MIP-2, KC, MIP-1alpha, MIP-1beta, Mi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(00)00351-9

    authors: Fischer FR,Santambrogio L,Luo Y,Berman MA,Hancock WW,Dorf ME

    更新日期:2000-10-02 00:00:00

  • Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

    abstract::Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00153-2

    authors: Laouini D,Kennou MF,Khoufi S,Dellagi K

    更新日期:1998-11-02 00:00:00

  • Tumour necrosis factor-alpha polymorphism and secretion in myasthenia gravis.

    abstract::The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00253-7

    authors: Huang DR,Pirskanen R,Matell G,Lefvert AK

    更新日期:1999-02-01 00:00:00