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Chronic restraint stress modulates expression of genes in murine spleen.

Abstract：

:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the spleens of restrained and unstressed mice using oligo microarrays consisting of 226 genes. We report here that mice subjected to chronic 12-h daily physical restraint for 2 days exhibited significantly altered expression of 50 of 226 genes. These genes included pro-apoptotic genes. We selected 5 genes of interest and confirmed the microarray results by real-time PCR. In this study, we identify a potentially important component of pro-apoptotic activity in restraint stress and suggest a possible target for anti-apoptotic therapy to protect splenocytes against stress-induced apoptosis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

doi

10.1016/j.jneuroim.2006.05.004

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

11-7

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00187-1

journal_volume

177

pub_type

杂志文章

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