Ketamine upregulates eNOS expression in human astroglial A172 cells: Possible role in its antidepressive properties.

abstract：:The expression of class I major histocompatibility complex (MHC) mRNA was compared in the brains of inflammatory susceptible, hypothalamic-pituitary-adrenal (HPA)-axis blunted Lewis rats and inflammatory resistant, HPA-axis hyperresponsive Fischer rats by quantitative in situ hybridization following lipopolysaccharide...

journal_title：Journal of neuroimmunology

authors： Puchowicz M,Tonelli LH,Sternberg EM

更新日期：2003-01-01 00:00:00

abstract：:The presence and severity of tardive dyskinesia were determined in 66 patients with chronic psychiatric disorders treated with chlorpromazine. The patients were classified according to the presence of antinuclear antibodies, the lupus anticoagulant, and the HLA antigen Bw44. The severity of orofacial dyskinesia was es...

journal_title：Journal of neuroimmunology

authors： Canoso RT,Romero JA,Yunis EJ

更新日期：1986-09-01 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:Activated CD4+ T lymphocytes specific for myelin basic protein (MBP) can cause experimental autoimmune encephalomyelitis (EAE) upon their inoculation into syngeneic recipients. In Lewis rats, most of the pathogenic T cell clones that develop following immunization with MBP are reactive against the 72-84 amino acid seq...

journal_title：Journal of neuroimmunology

authors： Beraud E,Balzano C,Zamora AJ,Varriale S,Bernard D,Ben-Nun A

更新日期：1993-08-01 00:00:00

abstract：:Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors...

journal_title：Journal of neuroimmunology

authors： Cosentino M,Zaffaroni M,Legnaro M,Bombelli R,Schembri L,Baroncini D,Bianchi A,Clerici R,Guidotti M,Banfi P,Bono G,Marino F

更新日期：2016-09-15 00:00:00

abstract：:IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12R beta 2) expression was investigated in experimental autoimmune uveitis (EAU) susc...

journal_title：Journal of neuroimmunology

authors： Wu Y,Lin Y,Hou W,Wang Y,Sun B

更新日期：2003-04-01 00:00:00

abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

更新日期：2015-06-15 00:00:00

abstract：:In this report, we have shown the expression of the complement regulatory proteins decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 on human D54-MG astroglioma cells by several methods, including immunofluorescence, flow cytometry and Western blotting and Northern blot analysis. Th...

journal_title：Journal of neuroimmunology

authors： Yang C,Jones JL,Barnum SR

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation. METHODS:1529 MS patients and 1814 controls from Sweden and Norway were g...

journal_title：Journal of neuroimmunology

authors： Link J,Lorentzen AR,Kockum I,Duvefelt K,Lie BA,Celius EG,Harbo HF,Hillert J,Brynedal B

更新日期：2010-09-14 00:00:00

abstract：:Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cell...

journal_title：Journal of neuroimmunology

authors： Tavakolpour V,Shokri G,Naser Moghadasi A,Mozafari Nahavandi P,Hashemi M,Kouhkan F

更新日期：2018-12-15 00:00:00

abstract：:Increases in the levels of proinflammatory cytokines, such as TNF alpha, have been intricately linked with arthritis and the pathogenesis of several models of neuropathic pain. In addition, arthritis (as well as other types of persistent pain) is associated with increased sympathetic activity and alterations of other ...

journal_title：Journal of neuroimmunology

authors： Chou RC,Dong XL,Noble BK,Knight PR,Spengler RN

更新日期：1998-03-01 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Transmitters and cotransmitters of the sympathetic nervous system are involved in the regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli lead to the release of these molecules in immune organs. In this study, we investigated whether local ischemia can cause the parallel re...

journal_title：Journal of neuroimmunology

authors： Sperlágh B,Dóda M,Baranyi M,Haskó G

更新日期：2000-11-01 00:00:00

abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

journal_title：Journal of neuroimmunology

authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

更新日期：1993-07-01 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG) is a well established animal model, which can be induced in various animal species and strains with acetylcholine receptor (AChR) and represents an experimental counterpart of human myasthenia gravis (MG). Current immunotherapies of both EAMG and MG are non-specific and...

journal_title：Journal of neuroimmunology

authors： Ma CG,Zhang GX,Xiao BG,Link J,Olsson T,Link H

更新日期：1995-04-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-α is involved in the pathogenesis of multiple scle...

journal_title：Journal of neuroimmunology

authors： Caminero A,Comabella M,Montalban X

更新日期：2011-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

journal_title：Journal of neuroimmunology

authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

更新日期：2019-09-15 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

journal_title：Journal of neuroimmunology

authors： Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

更新日期：1993-04-01 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:In the present work we investigated on rat splenocytes long-term interactions between opioid and cannabinoid drugs in terms of a common regulation of cAMP intracellular pathway. Both morphine and the synthetic cannabinoid compound CP-55,940 inhibited in a concentration-dependent manner the intracellular cAMP level in ...

journal_title：Journal of neuroimmunology

authors： Massi P,Vaccani A,Rubino T,Parolaro D

更新日期：2003-12-01 00:00:00

abstract：:Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

journal_title：Journal of neuroimmunology

authors： Vandevelde M,Zurbriggen A,Steck A,Bichsel P

更新日期：1986-03-01 00:00:00

abstract：:The present study was aimed at confirming the presence of GluR3 on T lymphocytes and to assess the effect of glutamate on proliferative responses to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) and chemotactic migration to CXCL12/stromal cell-derived factor-1, RANTES, and MIP-1alpha in 15 c...

journal_title：Journal of neuroimmunology

authors： Sarchielli P,Di Filippo M,Candeliere A,Chiasserini D,Mattioni A,Tenaglia S,Bonucci M,Calabresi P

更新日期：2007-08-01 00:00:00

abstract：:The pro-inflammatory cytokine IL-1β is known to play a role in several models of aging, neuroinflammation, and neurodegenerative diseases. Here, we document a detailed time- and age-dependent pattern of pro- and anti-inflammatory biomarkers following bilateral intrahippocampal injection of interleukin-1β. During the f...

journal_title：Journal of neuroimmunology

authors： Hopp SC,Royer S,Brothers HM,Kaercher RM,D'Angelo H,Bardou I,Wenk GL

更新日期：2014-02-15 00:00:00

abstract：:Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, follow...

journal_title：Journal of neuroimmunology

authors： Nischwitz S,Wolf C,Andlauer TF,Czamara D,Zettl UK,Rieckmann P,Buck D,Ising M,Bettecken T,Mueller-Myhsok B,Weber F

更新日期：2015-02-15 00:00:00

abstract：:Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to ...

journal_title：Journal of neuroimmunology

authors： Morris-Berry CM,Pollard M,Gao S,Thompson C,Tourette Syndrome Study Group.,Singer HS

更新日期：2013-11-15 00:00:00

abstract：:The expression of intercellular adhesion molecule-1 (ICAM-1) by human cerebral endothelium was studied in primary cultures of human brain microvessel endothelial cells following treatment with bacterial lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gam...

journal_title：Journal of neuroimmunology

authors： Wong D,Dorovini-Zis K

更新日期：1992-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

journal_title：Journal of neuroimmunology

authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

更新日期：2003-05-01 00:00:00