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Age-associated alterations in the time-dependent profile of pro- and anti-inflammatory proteins within the hippocampus in response to acute exposure to interleukin-1β.

Abstract：

:The pro-inflammatory cytokine IL-1β is known to play a role in several models of aging, neuroinflammation, and neurodegenerative diseases. Here, we document a detailed time- and age-dependent pattern of pro- and anti-inflammatory biomarkers following bilateral intrahippocampal injection of interleukin-1β. During the first 12h several pro- and anti-inflammatory cytokines increased in the aged (24 mo old) rats, some of which returned to baseline levels by 24h post-injection while others remained elevated for 72 h post-injection. In contrast, no such increases were observed in the young (3 mo old) rats. Interestingly, young rats up-regulated mRNA of two pro-inflammatory cytokines, interleukin-1β and tumor necrosis factor-α, but did not translate these transcripts into functional proteins, which may be related to expression of suppressor of cytokine signaling type-2. These results contribute to our understanding of how neuroinflammation may contribute to the pathogenesis of age-related neurodegenerative disorders due to an age-related bias towards a hyper-reactive immune response that is not selective for a pro- or anti-inflammatory phenotype following an inflammatory stimulus.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hopp SC,Royer S,Brothers HM,Kaercher RM,D'Angelo H,Bardou I,Wenk GL

doi

10.1016/j.jneuroim.2013.12.010

subject

Has Abstract

pub_date

2014-02-15 00:00:00

pages

86-91

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00353-6

journal_volume

267

pub_type

杂志文章

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