Abstract：
:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerable disturbances on the immune protective mechanisms. Thus, induction of antigen-specific immune tolerance remains the ultimate goal of MS therapy. Such approach carries promising therapeutic perspectives and, above all, a desirable safety profile. Several studies have been performed to evaluate highly selective, antigen-induced, therapies for experimental autoimmune encephalomyelitis (EAE) and MS. These trials have also indicated the importance of the antigen administration route. The continued efforts to develop efficient and safe MS therapy gave rise to the idea of incorporating the skin immune system in order to modulate autoimmunity in MS. Skin is the largest immunological organ of human body, and thus provides ample opportunities to modify immune responses. Skin dendritic cells have a significant ability to modulate the immune reactions, promoting either immunity or tolerance. Their capacity to induce tolerance has already been described in several experimental models of MS. In a one-year, double-blinded, placebo-controlled study assessing the effectiveness of transdermal myelin peptides patches, significant changes in the morphology of Langerhans cells (LCs) and shifts in the dendritic cell (DC) populations in the draining lymph nodes have been observed. In addition, patients treated with myelin patches showed a decreased brain inflammatory activity on MRI and a reduced relapse rate. In this review, we further discuss the potential to use skin-induced immune tolerance for MS treatment, with a particular focus on dermal DCs.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Wildner P,Selmaj KWdoi
10.1016/j.jneuroim.2017.08.001subject
Has Abstractpub_date
2017-10-15 00:00:00pages
49-58eissn
0165-5728issn
1872-8421pii
S0165-5728(17)30263-1journal_volume
311pub_type
杂志文章,评审abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...
journal_title：Journal of neuroimmunology
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2012.02.014
更新日期：2012-05-15 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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