当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.

Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.

Abstract：

:The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphocytes from patients with MS, optic neuritis (ON) and other inflammatory central nervous system (CNS) diseases. In patients with ON but not MS, increased expression of B7-2 was detected as compared to non-inflammatory controls. The expression of B7-1 in MS and ON patients correlates with disease duration but not with relapses in patients with MS indicating a role in early disease but not as a reliable marker of disease activity at later stages of MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Windhagen A,Maniak S,Gebert A,Ferger I,Heidenreich F

doi

10.1016/s0165-5728(99)00012-0

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

112-20

issue

1

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(99)00012-0

journal_volume

96

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Expression of neurotrophin receptors by proliferating glia in postischemic hippocampal CA1 sector of adult monkeys.

    abstract：:Transient global cerebral ischemia elicits a nearly total neuronal cell death in the hippocampal CA1 sector, accompanied by a marked microglial and astroglial proliferation. The molecular mechanisms regulating the postischemic glial reaction in the primate brain remain obscure. Here we present in situ evidence that pr...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.07.016

    authors： Tonchev AB,Boneva NB,Kaplamadzhiev DB,Kikuchi M,Mori Y,Sahara S,Yamashima T

    更新日期：2008-12-15 00:00:00

  • Increased plasma levels of high mobility group box 1 protein in patients with bipolar disorder: A pilot study.

    abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.576993

    authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

    更新日期：2019-09-15 00:00:00

  • TRPC6 gene variants and neuropsychiatric lupus.

    abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythem...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.08.015

    authors： Ramirez GA,Lanzani C,Bozzolo EP,Citterio L,Zagato L,Casamassima N,Canti V,Sabbadini MG,Rovere-Querini P,Manunta P,Manfredi AA

    更新日期：2015-11-15 00:00:00

  • Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus.

    abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(84)90067-5

    authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

    更新日期：1984-09-01 00:00:00

  • Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis.

    abstract：:The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of N...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00352-0

    authors： Schluesener HJ,Seid K

    更新日期：2000-10-02 00:00:00

  • The structure of a myelin basic protein-associated idiotope.

    abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90254-v

    authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

    更新日期：1993-07-01 00:00:00

  • Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

    abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.06.014

    authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

    更新日期：2010-10-08 00:00:00

  • Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.

    abstract：BACKGROUND:Although the role of inflammation in epilepsy pathogenesis has been extensively investigated, the inflammasome complex, a key component of neuroinflammation, has been understudied in epilepsy patients. METHODS:To better understand the involvement of this system in epilepsy, levels of inflammasome complex co...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577343

    authors： Ulusoy C,Vanlı-Yavuz EN,Şanlı E,Timirci-Kahraman Ö,Yılmaz V,Bebek N,Küçükali Cİ,Baykan B,Tüzün E

    更新日期：2020-10-15 00:00:00

  • Human myelin basic protein specific T cell lines display differential cytotoxicity against astrocytes, but are consistently cytotoxic against monocytes.

    abstract：:In experimental allergic encephalomyelitis (EAE) myelin basic protein (MBP) specific T cells differ in their encephalitogenic potential. To investigate the functional diversity of human MBP specific T cell lines, we analysed their cytotoxic activity against human astrocytes and monocytes. Five out of 14 MBP specific T...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00093-9

    authors： Weber F,Huber S,Aloisi F,Meinl E

    更新日期：1998-08-01 00:00:00

  • Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

    abstract：:Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.04.012

    authors： Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

    更新日期：2005-08-01 00:00:00

  • Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.

    abstract：:The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methylation of the SHP-1 p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.03.003

    authors： Kumagai C,Kalman B,Middleton FA,Vyshkina T,Massa PT

    更新日期：2012-05-15 00:00:00

  • Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments.

    abstract：:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, I...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jneuroim.2006.01.012

    authors： Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

    更新日期：2006-05-01 00:00:00

  • Lymphocyte proliferative response to glial cells in SJL/J mice immunized with rat whole spinal cord and rat myelin basic protein.

    abstract：:Lymph node cells (LNC) from SJL/J mice immunized with either rat whole spinal cord (WSC) homogenate or rat myelin basic protein (MBP) in the presence of complete Freund's adjuvant were assayed for their in vitro proliferative response to MBP and whole or sonicated purified oligodendrocytes (OD), and astrocytes. WSC-im...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90162-8

    authors： Jewtoukoff V,Bach MA

    更新日期：1989-01-01 00:00:00

  • Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing-remitting multiple sclerosis compared to healthy controls.

    abstract：:CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-funct...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.09.008

    authors： Haegele KF,Stueckle CA,Malin JP,Sindern E

    更新日期：2007-02-01 00:00:00

  • Differential binding patterns of anti-sulfatide antibodies to glial membranes.

    abstract：:Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.07.004

    authors： Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

    更新日期：2018-10-15 00:00:00

  • Effects of acute treatment with amphetamine in locomotor activity in sepsis survivor rats.

    abstract：:We here evaluated the central dopaminergic response in sepsis survivor rats using the administration of D-amphetamine. Male Wistar rats underwent cecal ligation and perforation (CLP) or were sham-operated. After 10 days of recovery, rats received an intraperitoneal injection of D-amphetamine 0.5, 1 and 2 mg/kg or sali...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.04.005

    authors： Comim CM,Constantino LS,Petronilho F,de Souza B,Barichello T,Quevedo J,Dal-Pizzol F

    更新日期：2009-07-25 00:00:00

  • Effect of repeated exercise stress on caspase 3, Bcl-2, HSP 70 and CuZn-SOD protein expression in mouse intestinal lymphocytes.

    abstract：:The purpose of this study was to characterize the expression of apoptosis (caspase 3, Bcl-2) and survival (HSP 70, antioxidant CuZn-SOD) proteins in intestinal lymphocytes (IL) of mice after repeated exercise stress. Plasma corticosterone concentration was greater than twofold higher immediately after exercise compare...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.04.012

    authors： Hoffman-Goetz L,Spagnuolo PA

    更新日期：2007-07-01 00:00:00

  • Astrocytes support mast cell viability in vitro.

    abstract：:Mast cells are normally found adjacent to blood vessels in the nervous system, and have been implicated in the development of inflammatory central nervous system (CNS) diseases such as experimental allergic encephalomyelitis. To further study mast cell-CNS interactions, we have developed a model in which viable rat pe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90056-q

    authors： Seeldrayers PA,Levin LA,Johnson D

    更新日期：1992-02-01 00:00:00

  • Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes.

    abstract：:We examined the potential expression and function of alpha7 nicotinic acetylcholine receptors (nAChRs) in leukocytes. RT-PCR with alpha7 specific primers revealed the presence of the receptor mRNA in leukocytes. Immunoblotting and immunofluorescence experiments demonstrated the expression of a protein that is recogniz...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00057-7

    authors： Villiger Y,Szanto I,Jaconi S,Blanchet C,Buisson B,Krause KH,Bertrand D,Romand JA

    更新日期：2002-05-01 00:00:00

  • T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice.

    abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90023-4

    authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

    更新日期：1989-05-01 00:00:00

  • T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects.

    abstract：:Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral blood of HLA-DR 15(2) MS patients were established which responded to the intact molecule of PLP. These TCL were then tested in individu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00260-9

    authors： Trotter JL,Pelfrey CM,Trotter AL,Selvidge JA,Gushleff KC,Mohanakumar T,McFarland HF

    更新日期：1998-04-15 00:00:00

  • Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.

    abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.08.008

    authors： Marra S,Burnett M,Hoffman-Goetz L

    更新日期：2005-01-01 00:00:00

  • Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.

    abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00158-9

    authors： Qiu Z,Gruol DL

    更新日期：2003-06-01 00:00:00

  • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

    abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.08.011

    authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

    更新日期：2010-12-15 00:00:00

  • NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.

    abstract：:Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Le...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00278-3

    authors： Bedoui S,Lechner S,Gebhardt T,Nave H,Beck-Sickinger AG,Straub RH,Pabst R,von Hörsten S

    更新日期：2002-11-01 00:00:00

  • Pathogenic and non-pathogenic T lymphocytes specific for the encephalitogenic epitope of myelin basic protein: functional characteristics and vaccination properties.

    abstract：:Activated CD4+ T lymphocytes specific for myelin basic protein (MBP) can cause experimental autoimmune encephalomyelitis (EAE) upon their inoculation into syngeneic recipients. In Lewis rats, most of the pathogenic T cell clones that develop following immunization with MBP are reactive against the 72-84 amino acid seq...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90283-5

    authors： Beraud E,Balzano C,Zamora AJ,Varriale S,Bernard D,Ben-Nun A

    更新日期：1993-08-01 00:00:00

  • Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection.

    abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90040-4

    authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

    更新日期：1989-04-01 00:00:00

  • Serum BAFF expression in patients with myasthenia gravis.

    abstract：:A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.05.010

    authors： Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

    更新日期：2008-08-13 00:00:00

  • The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.

    abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.10.018

    authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

    更新日期：2011-03-01 00:00:00

  • Band 1 and voltage-sensitive Na+ channels are not codistributed in cultured rodent neuronal cells.

    abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90028-x

    authors： Akeson R,Graham K

    更新日期：1981-09-01 00:00:00