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Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

Abstract：

:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent and human oligodendrocyte progenitor (OPC) cultures. Effects of Th2-polarized lines were stronger than Th1-polarized cells. Microarray and ELISA analyses revealed that neurotrophic factors induced in Th2- and Th1-polarized GA-reactive lines included IGF-2 and BMP-7 respectively, and functional studies confirmed IGF-2 as trophic for OPCs. Our results support the concept that GA therapy may result in supportive effects on oligodendrocytes in RRMS patients.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

doi

10.1016/j.jneuroim.2010.06.014

subject

Has Abstract

pub_date

2010-10-08 00:00:00

pages

71-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00269-9

journal_volume

227

pub_type

杂志文章

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