Activation of glial cells by human coronavirus OC43 infection.

abstract：:A 20 h continuous treatment of rats with catecholamines, using subcutaneously implantable retard tablets, had either no (adrenaline, isoproterenol, midodrine) or a slight (noradrenaline) suppressive effect on the in vitro responsiveness of peripheral blood T-lymphocytes. A marked suppression of the mitogen response en...

journal_title：Journal of neuroimmunology

authors： Felsner P,Hofer D,Rinner I,Mangge H,Gruber M,Korsatko W,Schauenstein K

更新日期：1992-03-01 00:00:00

abstract：:Endogenous hypothalamic pro-inflammatory cytokines modulate the hypothalamic-pituitary-adrenal (HPA) axis responses. To investigate whether hypothalamic IL-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are associated with differential inflammatory susceptibilities between Lewis (LEW/N) and Fischer (F344/N) ...

journal_title：Journal of neuroimmunology

authors： Wei R,Listwak SJ,Sternberg EM

更新日期：2003-02-01 00:00:00

abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

journal_title：Journal of neuroimmunology

authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

更新日期：2001-02-15 00:00:00

abstract：:Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treat...

journal_title：Journal of neuroimmunology

authors： Lalive PH,Kantengwa S,Benkhoucha M,Juillard C,Chofflon M

更新日期：2008-07-15 00:00:00

abstract：:We investigated T cell epitopes of guinea pig myelin basic protein (MBP) that induce experimental autoimmune encephalomyelitis (EAE) in DA rats, using synthetic peptides that correspond to regions of the guinea pig MBP molecule that are homologous to rat MBP. Four peptides were encephalitogenic when tested in DA rats....

journal_title：Journal of neuroimmunology

authors： Stepaniak JA,Wolf NA,Sun D,Swanborg RH

更新日期：1997-09-01 00:00:00

abstract：:Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

journal_title：Journal of neuroimmunology

authors： Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

更新日期：2014-03-15 00:00:00

abstract：:Demyelination, a pathological hallmark of multiple sclerosis, may be a necessary but not a sufficient condition for motor dysfunction associated with this disease. We favor a neurodegenerative model of multiple sclerosis and suggest that demyelination creates a permissive environment wherein the denuded axon becomes s...

journal_title：Journal of neuroimmunology

authors： Howe CL,Ure D,Adelson JD,LaFrance-Corey R,Johnson A,Rodriguez M

更新日期：2007-08-01 00:00:00

abstract：:Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evalu...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Vieira ÉLM,Dos Reis Bastos J,Ferreira RN,Nicoli JR,Teixeira MM,Vieira LQ,Moreira FA,Teixeira AL

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Postpartum is a period of unique psychosocial stress characterized by sleep disturbance, risk for depressed mood, and heightened parenting stress. However, data on effects of these exposures on inflammatory immune function are limited. METHODS:This study examined associations among sleep, psychosocial stres...

journal_title：Journal of neuroimmunology

authors： Christian LM,Kowalsky JM,Mitchell AM,Porter K

更新日期：2018-03-15 00:00:00

abstract：:This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without tr...

journal_title：Journal of neuroimmunology

authors： Sadowska-Bartosz I,Adamczyk-Sowa M,Gajewska A,Bartosz G

更新日期：2014-01-15 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:In previous work on sigma (sigma) receptors, we established a hybridoma cell line, 10G9, producing a monoclonal anti-idiotypic antibody (anti-Id mAb) to the monoclonal and anti-haloperidol antibody. The anti-Id mAb showed specific binding affinity to sigma receptors in immunoprecipitation and competition experiments. ...

journal_title：Journal of neuroimmunology

authors： Kobayashi T,Togashi S,Itoh N,Kumanishi T

更新日期：1995-03-01 00:00:00

abstract：:Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with...

journal_title：Journal of neuroimmunology

authors： Poli L,De Giuli V,Piazza F,Volonghi I,Bigliardi G,Vallone S,Nichelli PF,Gasparotti R,Zini A,Padovani A,Pezzini A

更新日期：2020-01-15 00:00:00

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:In this report, we have shown the expression of the complement regulatory proteins decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 on human D54-MG astroglioma cells by several methods, including immunofluorescence, flow cytometry and Western blotting and Northern blot analysis. Th...

journal_title：Journal of neuroimmunology

authors： Yang C,Jones JL,Barnum SR

更新日期：1993-09-01 00:00:00

abstract：:We studied glial transforming growth factor (TGF)-beta isotype expression in 14 cases of multiple sclerosis. Acute active lesions exhibited selective TGF-beta 2 immunoreactivity of lesion encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions expressed all three isotypes. Chr...

journal_title：Journal of neuroimmunology

authors： Peress NS,Perillo E,Seidman RJ

更新日期：1996-12-01 00:00:00

abstract：:Axonal injury is the major cause of disability in patients with multiple sclerosis (MS), but the mechanisms leading to axonal damage are poorly understood. Oligoclonal IgM against lipids predicts an aggressive disease course in MS; however, the antigen that elicits the immune response has not yet been identified. We s...

journal_title：Journal of neuroimmunology

authors： Beltrán E,Hernández A,Lafuente EM,Coret F,Simó-Castelló M,Boscá I,Pérez-Miralles FC,Burgal M,Casanova B

更新日期：2012-06-15 00:00:00

abstract：:Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL/6 mice that overexpress a T...

journal_title：Journal of neuroimmunology

authors： Martinez NE,Sato F,Omura S,Kawai E,Takahashi S,Yoh K,Tsunoda I

更新日期：2014-11-15 00:00:00

abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

journal_title：Journal of neuroimmunology

authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

更新日期：2002-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells ...

journal_title：Journal of neuroimmunology

authors： Peron JP,Yang K,Chen ML,Brandao WN,Basso AS,Commodaro AG,Weiner HL,Rizzo LV

更新日期：2010-10-08 00:00:00

abstract：OBJECTIVE:Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese. METHODS:205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for h...

journal_title：Journal of neuroimmunology

authors： Zhu WH,Lu JH,Lin J,Xi JY,Lu J,Luo SS,Qiao K,Xiao BG,Lu CZ,Zhao CB

更新日期：2012-06-15 00:00:00

abstract：:The proportions of CD2+, CD4+ and CD8+ lymphocytes were determined with the 3-layer indirect immunoperoxidase technique in the cerebrospinal fluid (CSF) of 31 patients with myasthenia gravis (MG) and 21 control subjects without autoimmune or central nervous system (CNS) diseases. None of the MG patients were using imm...

journal_title：Journal of neuroimmunology

authors： Müller KM,Taskinen E,Iivanainen M

更新日期：1990-12-01 00:00:00

abstract：:Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

journal_title：Journal of neuroimmunology

authors： Cedeño N,Urbina M,Obregón F,Lima L

更新日期：2005-02-01 00:00:00

abstract：:The surface receptors involved in natural killer (NK) cell triggering during the process of target cell lysis have been at least in part identified. These are members of a novel family of receptors that has been termed natural cytotoxicity receptors (NCR). The first three members of this emerging group of receptors ar...

journal_title：Journal of neuroimmunology

authors： Sivori S,Parolini S,Marcenaro E,Castriconi R,Pende D,Millo R,Moretta A

更新日期：2000-07-24 00:00:00

abstract：:Neuronal apoptosis has recently been implicated in multiple sclerosis (MS). Apoptotic cell death of neurons is induced in cultures exposed to cerebrospinal fluid (CSF) from MS patients. Since caspases are essential in the regulation of apoptosis, direct evidence was sought linking caspases to CSF-induced neuronal deat...

journal_title：Journal of neuroimmunology

authors： Cid C,Alvarez-Cermeño JC,Regidor I,Plaza J,Salinas M,Alcázar A

更新日期：2003-03-01 00:00:00

abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

journal_title：Journal of neuroimmunology

authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

更新日期：1990-03-01 00:00:00

abstract：:Contradictory results have been reported regarding the role of inflammatory mediators in the central nervous system in mediating neuropathic pain and inflammatory hyperalgesia following peripheral nerve injury or localized inflammation. The present study aims to correlate between the mRNA expression and protein secret...

journal_title：Journal of neuroimmunology

authors： Chamaa F,Chebaro M,Safieh-Garabedian B,Saadeh R,Jabbur SJ,Saadé NE

更新日期：2016-08-15 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：:Transmitters and cotransmitters of the sympathetic nervous system are involved in the regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli lead to the release of these molecules in immune organs. In this study, we investigated whether local ischemia can cause the parallel re...

journal_title：Journal of neuroimmunology

authors： Sperlágh B,Dóda M,Baranyi M,Haskó G

更新日期：2000-11-01 00:00:00

abstract：:The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression i...

journal_title：Journal of neuroimmunology

authors： André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

更新日期：2008-08-30 00:00:00