Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis.

abstract：:Inflammatory reactions in the CNS, resulting from a loss of control and involving a network of non-neuronal and neuronal cells, are major contributors to the onset and progress of several major neurodegenerative diseases. Therapeutic strategies should therefore keep or restore the well-controlled and finely-tuned bala...

journal_title：Journal of neuroimmunology

authors： Häke I,Schönenberger S,Neumann J,Franke K,Paulsen-Merker K,Reymann K,Ismail G,Bin Din L,Said IM,Latiff A,Wessjohann L,Zipp F,Ullrich O

更新日期：2009-01-03 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...

journal_title：Journal of neuroimmunology

authors： Quan N,Stern EL,Whiteside MB,Herkenham M

更新日期：1999-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multi...

journal_title：Journal of neuroimmunology

authors： Molnarfi N,Benkhoucha M,Juillard C,Bjarnadóttir K,Lalive PH

更新日期：2014-02-15 00:00:00

abstract：:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. It...

journal_title：Journal of neuroimmunology

authors： Hammann KP,Hopf HC

更新日期：1986-11-01 00:00:00

abstract：:IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide. We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity),...

journal_title：Journal of neuroimmunology

authors： Campagnolo M,Ferrari S,Dalla Torre C,Cabrini I,Cacciavillani M,Lucchetta M,Ruggero S,Toffanin E,Cavallaro T,Briani C

更新日期：2015-04-15 00:00:00

abstract：:The pharmacological profile and the anatomical localisation of muscarinic cholinergic receptor subtypes were studied in the pigeon bursa of Fabricius, using radioligand binding and autoradiographic techniques with [3H]quinuclidinyl benzilate (QNB) as a ligand. [3H]QNB was specifically bound to sections of bursa of Fab...

journal_title：Journal of neuroimmunology

authors： Ricci A,Bronzetti E,Felici L,Ciriaco E,Vega JA,Germanà G

更新日期：1996-05-01 00:00:00

abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

journal_title：Journal of neuroimmunology

authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

更新日期：1983-06-01 00:00:00

abstract：:The in vivo effects on the expression of adhesion molecules and on the adhesion between mononuclear cells and multiple sclerosis human brain endothelial cells (MS-HBECs) were investigated at the beginning of beta-IFN-1b treatment of MS patients. MS-HBECs were isolated from a surgical specimen obtained from an MS patie...

journal_title：Journal of neuroimmunology

authors： Corsini E,Gelati M,Dufour A,Massa G,Nespolo A,Ciusani E,Milanese C,La Mantia L,Salmaggi A

更新日期：1997-10-01 00:00:00

abstract：:Interleukin-10 is a potent immunomodulatory cytokine with possible implications for the pathogenesis of multiple sclerosis. Increased IL10 mRNA expression is associated with stable disease. The interleukin 10 gene is highly polymorphic and certain haplotypes result in differential interleukin-10 expression. The presen...

journal_title：Journal of neuroimmunology

authors： Mäurer M,Kruse N,Giess R,Toyka KV,Rieckmann P

更新日期：2000-04-03 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

journal_title：Journal of neuroimmunology

authors： Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

更新日期：1986-03-01 00:00:00

abstract：:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which i...

journal_title：Journal of neuroimmunology

authors： Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

更新日期：2005-10-01 00:00:00

abstract：:Immunoelectron microscopical techniques have been used to study class II major histocompatibility complex (MHC) expression by cells in the spinal cords of Biozzi AB/H mice with chronic relapsing experimental allergic encephalomyelitis. Throughout the course of disease both astrocytes and endothelia failed to express s...

journal_title：Journal of neuroimmunology

authors： Butter C,O'Neill JK,Baker D,Gschmeissner SE,Turk JL

更新日期：1991-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-asso...

journal_title：Journal of neuroimmunology

authors： Puttini S,Panaite PA,Mermod N,Renaud S,Steck AJ,Kuntzer T

更新日期：2014-05-15 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has well recognized effects on cerebral endothelial cells and, therefore, may mediate disruption of blood-brain barrier in patients with multiple sclerosis (MS). To evaluate the in vivo relationship of TNF-alpha to blood-brain barrier impairment in MS, levels of this cytokine in...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Thompson EJ

更新日期：1992-05-01 00:00:00

abstract：:Receptors for VIP in mouse peritoneal macrophages (MPM) were examined using [125I]labeled VIP as ligand. The receptor binding was rapid, reversible, saturable, specific, and dependent on time, pH, temperature and cell concentration. At 15 degrees C, the stoichiometric data suggested the presence of two classes of VIP ...

journal_title：Journal of neuroimmunology

authors： Calvo JR,Montilla ML,Guerrero JM,Segura JJ

更新日期：1994-02-01 00:00:00

abstract：:The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression i...

journal_title：Journal of neuroimmunology

authors： André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

更新日期：2008-08-30 00:00:00

abstract：:We investigated the expression and production of the interleukin-1 receptor antagonist (IL-1ra) in three human glioblastoma cell lines (LN443, LN444, LN859). Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of IL-1ra mRNA transcripts in the three cell lines. These three cell lines a...

journal_title：Journal of neuroimmunology

authors： Tada M,Diserens AC,Desbaillets I,Jaufeerally R,Hamou MF,de Tribolet N

更新日期：1994-03-01 00:00:00

abstract：:T helper 2 (Th2) cytokines are known to be important in protection against experimental autoimmune encephalomyelitis (EAE). To investigate the role of the signal transducer and activator of transcription factor 6 (STAT6) in EAE we used mice with two different targeted disruptions of the STAT6 gene. In this report, we ...

journal_title：Journal of neuroimmunology

authors： Wang Y,Evans JT,Rodriguez F,Fields P,Mueller C,Chitnis T,Khoury SJ,Bynoe MS

更新日期：2009-01-03 00:00:00

abstract：:We have analyzed the impact of stroke with subsequent hemiparesis and sensory loss on in vivo mediated immune functions. The delayed-type hypersensitivity (DTH) reaction to purified protein derivate (PPD, tuberculin) was used as a measure of antigen-specific T-cell reactivity, and subcutaneous immunization with influe...

journal_title：Journal of neuroimmunology

authors： Tarkowski E,Ekelund P,Tarkowski A

更新日期：1991-10-01 00:00:00

abstract：:Programmed death-1 (PD-1) belongs to the CD28 family of co-stimulatory and co-inhibitory molecules and regulates adaptive immunity. This molecule induces the development of regulatory T cells, T cell tolerance, or apoptosis. We examined the role of PD-1 pathway in Theiler's murine encephalomyelitis virus (TMEV)-induce...

journal_title：Journal of neuroimmunology

authors： Takizawa S,Kaneyama T,Tsugane S,Takeichi N,Yanagisawa S,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2014-09-15 00:00:00

abstract：:SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot of chick retinal proteins at 21 days after intravitreal injection with 5 or 10 microM/eye Glu showed decreases in 37, 42, 53 and 57 kDa proteins and increases in 35, 72 and >94 kDa proteins. These proteins were carboxylases except for the 35 and 37 kDa...

journal_title：Journal of neuroimmunology

authors： Sattayasai N,Sattayasai J,Daduang S,Chahomchuen T,Ketkaew S,Puchongkavarin H

更新日期：2003-08-01 00:00:00

abstract：:CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant co...

journal_title：Journal of neuroimmunology

authors： Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi A

更新日期：1998-02-01 00:00:00

abstract：:Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced neuroinflammation which was cha...

journal_title：Journal of neuroimmunology

authors： Xia MX,Ding X,Qi J,Gu J,Hu G,Sun XL

更新日期：2014-08-15 00:00:00

abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

journal_title：Journal of neuroimmunology

authors： McCue D,Ryan KR,Wraith DC,Anderton SM

更新日期：2004-11-01 00:00:00

abstract：:The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical...

journal_title：Journal of neuroimmunology

authors： Zivković IP,Rakin AK,Petrović-Djergović DM,Kosec DJ,Mićić MV

更新日期：2005-03-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscle's proteomi...

journal_title：Journal of neuroimmunology

authors： Gomez AM,Vanheel A,Losen M,Molenaar PC,De Baets MH,Noben JP,Hellings N,Martinez-Martinez P

更新日期：2013-08-15 00:00:00

abstract：:Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to ...

journal_title：Journal of neuroimmunology

authors： Morris-Berry CM,Pollard M,Gao S,Thompson C,Tourette Syndrome Study Group.,Singer HS

更新日期：2013-11-15 00:00:00

abstract：:The 802-2 peptide, designed from the conserved D1-CC' loop region of human CD4, can disrupt CD4(+) T cell activation in both human and murine systems. Here, 802-2 was investigated for efficacy in acute murine experimental allergic encephalomyelitis (EAE) models, and was found to significantly reduce the severity of di...

journal_title：Journal of neuroimmunology

authors： Edling AE,Choksi S,Huang Z,Korngold R

更新日期：2001-01-01 00:00:00