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Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

Abstract：

:Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscle's proteomic profile at different stages of experimental autoimmune myasthenia gravis (EAMG). We identified twenty-two differentially expressed proteins, mainly related to metabolic and stress-response pathways. Interestingly, these identified proteins have also been associated with other contraction-impairing muscle pathologies (e.g. inclusion body myositis), suggesting a similar response of the muscle to such conditions.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Gomez AM,Vanheel A,Losen M,Molenaar PC,De Baets MH,Noben JP,Hellings N,Martinez-Martinez P

doi

10.1016/j.jneuroim.2013.05.008

keywords:

["2D-DIGE","Autoimmunity","Muscle proteomics","Myasthenia gravis"]

subject

Has Abstract

pub_date

2013-08-15 00:00:00

pages

141-5

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00140-9

journal_volume

261

pub_type

杂志文章

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