The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.


:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of tyrosine kinases such as JAK2 and TYK2. Treatment of SJL/J mice with SOCS1-KIR beginning 12 days post-immunization with myelin basic protein (MBP) resulted in minimal symptoms of EAE, while most control treated mice developed paraplegia. SOCS1-KIR treatment suppressed interleukin-17A (IL-17A) production by MBP-specific lymphocytes, as well as MBP-induced lymphocyte proliferation. When treated with IL-23, a key cytokine in the terminal differentiation of IL-17-producing cells, MBP-sensitized cells produced IL-17A and IFNγ; SOCS1-KIR was able to inhibit the production of these cytokines. SOCS1-KIR also blocked IL-23 and IL-17A activation of STAT3. There is a deficiency of SOCS-1 and SOCS-3 mRNA expression in CD4(+) T cells that infiltrate the CNS, reflecting a deficiency in regulation. Consistent with therapeutic efficacy, SOCS1-KIR reversed the cellular infiltration of the CNS that is associated with EAE. We have shown here that a SOCS-1 like effect can be obtained with a small functional region of the SOCS-1 protein that is easily produced.


J Neuroimmunol


Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM




Has Abstract


2011-03-01 00:00:00














  • Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain.

    abstract::Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced neuroinflammation which was cha...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Xia MX,Ding X,Qi J,Gu J,Hu G,Sun XL

    更新日期:2014-08-15 00:00:00

  • Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus.

    abstract::Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Michalovicz LT,Lally B,Konat GW

    更新日期:2015-08-15 00:00:00

  • MicroRNA expression profiling in Guillain-Barré syndrome.

    abstract::Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we foun...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

    更新日期:2016-12-15 00:00:00

  • Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters.

    abstract::A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

    更新日期:2006-08-01 00:00:00

  • Differential binding patterns of anti-sulfatide antibodies to glial membranes.

    abstract::Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

    更新日期:2018-10-15 00:00:00

  • Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis.

    abstract::Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lyman WD,Sonett JR,Brosnan CF,Elkin R,Bornstein MB

    更新日期:1989-06-01 00:00:00

  • Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis.

    abstract::Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Willenborg DO,Prowse SJ

    更新日期:1983-10-01 00:00:00

  • Experimental autoimmune encephalomyelitis: isolation and characterization of inflammatory cells from the central nervous system.

    abstract::Lymphocytes from the central nervous system (CNS) of animals with acute experimental autoimmune encephalomyelitis (EAE) have been isolated and characterized. The lymphocytes were separated from Lewis rats which were injected either with an emulsion of myelin basic protein (BP) emulsified in complete Freund's adjuvant ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lyman WD,Abrams GA,Raine CS

    更新日期:1989-12-01 00:00:00

  • No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.

    abstract::Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sulonen AM,Kallio SP,Ellonen P,Suvela M,Elovaara I,Koivisto K,Pirttilä T,Reunanen M,Tienari PJ,Palotie A,Peltonen L,Saarela J

    更新日期:2009-01-03 00:00:00

  • Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury.

    abstract::Immunological events occurring in the central nervous system (CNS) as a result of head trauma are largely unexplored. We report here that the levels of the alternative pathway complement proteins C3 and factor B are elevated in the cerebrospinal fluid (CSF) of head-injured patients. C3 and factor B indices suggest tha...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kossmann T,Stahel PF,Morganti-Kossmann MC,Jones JL,Barnum SR

    更新日期:1997-03-01 00:00:00

  • Regional topographical differences of canine microglial immunophenotype and function in the healthy spinal cord.

    abstract::Differences in the regulation of surface molecule expression and functional activity of microglia, the resident immune effector elements of the central nervous system (CNS), might give important insights into understanding the predilection sites of some diseases within the CNS. Therefore, canine microglial cells in re...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ensinger EM,Boekhoff TM,Carlson R,Beineke A,Rohn K,Tipold A,Stein VM

    更新日期:2010-10-08 00:00:00

  • Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients.

    abstract::The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydroc...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章


    authors: Provencio JJ,Kivisäkk P,Tucky BH,Luciano MG,Ransohoff RM

    更新日期:2005-06-01 00:00:00

  • Modulation of acetylcholine receptor function in TE671 (rhabdomyosarcoma) cells by non-AChR ligands: possible relevance to seronegative myasthenia gravis.

    abstract::The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Li Z,Forester N,Vincent A

    更新日期:1996-02-01 00:00:00

  • Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

    abstract::Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

    更新日期:2014-03-15 00:00:00

  • TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents.

    abstract::The aggregation and deposition of transactivation response DNA-binding protein 43 (TDP-43) in neurons and astrocytes is characteristic in a number of neurodegenerative diseases including Alzheimer's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. Nevertheless, the exact role of TDP-43 in...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huang CY,Lee YC,Li PC,Liliang PC,Lu K,Wang KW,Chang LC,Shiu LY,Chen MF,Sun YT,Wang HK

    更新日期:2017-12-15 00:00:00

  • Studies on the intrathecal humoral immune response in canine distemper encephalitis.

    abstract::Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vandevelde M,Zurbriggen A,Steck A,Bichsel P

    更新日期:1986-03-01 00:00:00

  • Type 1 immune response in progressive multiple sclerosis.

    abstract::The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

    更新日期:2012-08-15 00:00:00

  • Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation.

    abstract::The immunosuppressive nature of glucocorticoids has been well documented both in vitro and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in immune cells within the central nervous system (CNS). For example, microglia have previously been shown to exhibit decreased proliferation, cytoki...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Nair A,Bonneau RH

    更新日期:2006-02-01 00:00:00

  • Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly.

    abstract::Stroke is the leading cause of death and the main cause of disability in surviving patients. The detrimental interaction between immune cells, glial cells, and matrix components in stroke pathology results in persistent inflammation that progresses to fibrosis. A substantial effort is being directed toward understandi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Amruta N,Rahman AA,Pinteaux E,Bix G

    更新日期:2020-07-09 00:00:00

  • CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

    abstract::The role of CD8⁺ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8⁺ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Camara M,Beyersdorf N,Fischer HJ,Herold MJ,Ip CW,van den Brandt J,Toyka KV,Taurog JD,Hünig T,Herrmann T,Reichardt HM,Weishaupt A,Kerkau T

    更新日期:2013-07-15 00:00:00

  • Interleukin-1 activity in lesioned peripheral nerve.

    abstract::The cytokine interleukin-1 (IL-1) is involved in a wide range of inflammatory and immune responses. As such, IL-1 could play a role in peripheral nerve repair mechanisms. Specifically, by its already established properties as a regulator of nerve growth factor (NGF) synthesis, and as a chemotactant to macrophages. We ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rotshenker S,Aamar S,Barak V

    更新日期:1992-07-01 00:00:00

  • Low-dosage of rituximab in Chinese patients with neuromyelitis optica spectrum disorder.

    abstract::Rituximab has been effectively used for treating neuromyelitis optica spectrum disorder (NMOSD) for several years. However those regimens exert a heavy burden on Chinese patients. The aim of our study was to investigate an effectiveness, economic alternatives of RTX. The enrolled patients received different immunosupp...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章


    authors: Lin J,Li X,Xue B,Tong Q,Chen Z,Zhu W,Li J,Xia J

    更新日期:2018-04-15 00:00:00

  • Successful combined treatment with thymectomy, rituximab and tocilizumab for severe thymoma-associated multi autoimmune syndrome.

    abstract::We present a 53-year-old woman who presented simultaneously with acute inflammatory demyelinating polyneuropathy, Graves' disease, leukocytoclastic vasculitis, elevated acetylcholine antibody receptor antibodies and a mediastinal mass. Thymectomy was performed and revealed a type A thymoma and the clinical picture and...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sveinsson O,Piehl F,Aspegren O,Hietala MA

    更新日期:2019-11-15 00:00:00

  • The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

    abstract::Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to al...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

    更新日期:2005-10-01 00:00:00

  • Effects of dexamethasone on microglial activation in vivo: selective downregulation of major histocompatibility complex class II expression in regenerating facial nucleus.

    abstract::Following axotomy of the facial nerve microglial cells in the facial nucleus become activated, proliferate, and newly express class I and class II major histocompatibility complex (MHC) antigens. Dexamethasone treatment, starting 2 days prior to axotomy at 1 mg/kg/day, selectively inhibited axotomy-induced MHC class I...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kiefer R,Kreutzberg GW

    更新日期:1991-11-01 00:00:00

  • NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.

    abstract::Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Le...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Bedoui S,Lechner S,Gebhardt T,Nave H,Beck-Sickinger AG,Straub RH,Pabst R,von Hörsten S

    更新日期:2002-11-01 00:00:00

  • Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders.

    abstract::Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent fin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Reindl M,Khantane S,Ehling R,Schanda K,Lutterotti A,Brinkhoff C,Oertle T,Schwab ME,Deisenhammer F,Berger T,Bandtlow CE

    更新日期:2003-12-01 00:00:00

  • Interferon-beta impairs induction of HLA-DR antigen expression in cultured adult human astrocytes.

    abstract::We studied the effect of interferons on the expression of class II histocompatibility (HLA-DR) antigens by cultured adult human astrocytes. Cultures were derived from brain tissue resected for surgical treatment of intractable epilepsy. Cultured astrocytes did not spontaneously display HLA-DR antigen as determined by ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Barna BP,Chou SM,Jacobs B,Yen-Lieberman B,Ransohoff RM

    更新日期:1989-06-01 00:00:00

  • The significance of abnormal immune responses in patients with multiple sclerosis.

    abstract::Early diagnosis of multiple sclerosis (MS) may be assisted by tests for the abnormal immune responses of the central nervous system (CNS) including oligoclonal IgG bands in the cerebrospinal fluid (CSF), increased CNS IgG synthesis, increased CNS antibody synthesis against multiple viruses and increased numbers of enl...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Iivanainen MV

    更新日期:1981-06-01 00:00:00

  • Dendritic cells presenting pyruvate kinase M1/M2 isozyme peptide can induce experimental allergic myositis in BALB/c mice.

    abstract::Polymyositis (PM) is an inflammatory muscle disease caused by autoimmune dysfunction, considered to be caused by cytotoxic CD8 T cells. To date, no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DC) presenting p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kawachi I,Tanaka K,Tanaka M,Tsuji S

    更新日期:2001-07-02 00:00:00