(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.


:A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, interleukin (IL)-2 and interferon (IFN)-gamma production. In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-gamma production stimulated with anti-CD3/28. These findings highlight the fact that LLDT-8 prevents EAE by suppressing T cell proliferation and activation, with a potential for treatment of MS.


J Neuroimmunol


Fu YF,Zhu YN,Ni J,Zhong XG,Tang W,Zhou R,Zhou Y,Dong JR,He PL,Wan H,Li YC,Yang YF,Zuo JP




Has Abstract


2006-06-01 00:00:00














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    pub_type: 杂志文章


    authors: De la Fuente M,Del Río M,Medina S

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  • Interferon beta in multiple sclerosis: relationship between sustained serum IgG levels and clinical outcome.

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    journal_title:Journal of neuroimmunology

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    authors: Dubucquoi S,de Seze J,Lefranc D,Almeras L,Dutoit V,Prin L,Vermersch P

    更新日期:2002-08-01 00:00:00

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    abstract::The timing and intensity of the antibody responses to the marker determinants of synthetic peptide S81 and S82 sequences of bovine myelin basic protein (MBP) (residues 68-83 and 65-83, respectively) were studied in 20 Lewis rats and 6 rabbits. All rats immunized with either peptide in CFA responded with antibody devel...

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    authors: Day ED,Hashim GA,Varitek VA Jr,Paterson PY

    更新日期:1981-06-01 00:00:00

  • Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.

    abstract::The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

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    pub_type: 杂志文章


    authors: Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

    更新日期:2007-12-01 00:00:00

  • The C5a complement activation peptide increases IL-1beta and IL-6 release from amyloid-beta primed human monocytes: implications for Alzheimer's disease.

    abstract::Alzheimer's disease (AD) brains contain large numbers of amyloid-beta peptide (Abeta) deposits associated with activated microglia, astrocytes and dystrophic neurites. Activated complement components and pro-inflammatory cytokines are also present, indicative of focal inflammation. However, neither Abeta, nor the chem...

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    pub_type: 杂志文章


    authors: O'Barr S,Cooper NR

    更新日期:2000-09-22 00:00:00

  • Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy.

    abstract::We have recently demonstrated that ConA-induced suppressor cell function is defective in chronic inflammatory demyelinating polyneuropathy (CIDP). To assess whether this defect plays a role in disease activity and its reversal is important in recovery, we studied modifications of ConA-induced suppressor cell function ...

    journal_title:Journal of neuroimmunology

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    authors: De Luca G,Lugaresi A,Iarlori C,Marzoli F,Di Iorio A,Gambi D,Uncini A

    更新日期:1999-03-01 00:00:00

  • A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein.

    abstract::Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mendel I,Natarajan K,Ben-Nun A,Shevach EM

    更新日期:2004-04-01 00:00:00

  • A genome screen for linkage disequilibrium in Turkish multiple sclerosis.

    abstract::In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for as...

    journal_title:Journal of neuroimmunology

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    authors: Eraksoy M,Hensiek A,Kurtuncu M,Akman-Demir G,Kilinc M,Gedizlioglu M,Petek-Balci B,Anlar O,Kutlu C,Saruhan-Direskeneli G,Idrisoglu HA,Setakis E,Compston A,Sawcer S,Turkish Multiple Sclerosis Genetics Study Group.

    更新日期:2003-10-01 00:00:00

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    abstract::We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Akaishi T,Nakashima I,Mugikura S,Aoki M,Fujihara K

    更新日期:2017-05-15 00:00:00

  • Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein.

    abstract::Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

    更新日期:1993-04-01 00:00:00

  • Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes.

    abstract::Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hohlfeld R,Toyka KV

    更新日期:1985-08-01 00:00:00

  • ATP and adenosine induce ramification of microglia in vitro.

    abstract::Microglial cells in the healthy adult brain possess a characteristic ramified morphology with multiple branched processes, small somata and down-regulated inflammatory properties. In contrast, microglial cells isolated from new-born rat brain inevitably show a non-ramified amoeboid phenotype, which is observed in vivo...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wollmer MA,Lucius R,Wilms H,Held-Feindt J,Sievers J,Mentlein R

    更新日期:2001-04-02 00:00:00

  • Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis.

    abstract::Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Daverat P,Geffard M,Orgogozo JM

    更新日期:1989-04-01 00:00:00

  • Intracerebroventricular interleukin-1beta impairs clearance of tumor cells from the lungs: role of brain prostaglandins.

    abstract::We have previously demonstrated that central administration of interleukin (IL)-1beta suppresses natural killer (NK) cell activity, impairs NK-mediated lung clearance of tumor cells, and enhances tumor colonization. The central pathways activated by IL-1beta are as yet unknown. Using an in vivo model of tumor coloniza...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hodgson DM,Yirmiya R,Taylor AN

    更新日期:2001-09-03 00:00:00

  • T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

    abstract::The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T ce...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Schliffke S,Carambia A,Akyüz N,Thiele B,Herkel J,Binder M

    更新日期:2019-07-15 00:00:00

  • Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients.

    abstract::The present study was aimed at confirming the presence of GluR3 on T lymphocytes and to assess the effect of glutamate on proliferative responses to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) and chemotactic migration to CXCL12/stromal cell-derived factor-1, RANTES, and MIP-1alpha in 15 c...

    journal_title:Journal of neuroimmunology

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    authors: Sarchielli P,Di Filippo M,Candeliere A,Chiasserini D,Mattioni A,Tenaglia S,Bonucci M,Calabresi P

    更新日期:2007-08-01 00:00:00

  • Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord.

    abstract::Tumor necrosis factor alpha (TNFalpha) activity was measured in serum and cerebrospinal fluid (CSF) of Lewis rats after experimental allergic encephalomyelitis (EAE) induction and during the clinical course of acute disease. TNFalpha bioactivity expression preceded the clinical symptoms and paralleled the severity of ...

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    pub_type: 杂志文章


    authors: Villarroya H,Violleau K,Ben Younes-Chennoufi A,Baumann N

    更新日期:1996-01-01 00:00:00

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    abstract::NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

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    authors: Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

    更新日期:2008-05-30 00:00:00

  • Ketamine upregulates eNOS expression in human astroglial A172 cells: Possible role in its antidepressive properties.

    abstract::Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

    journal_title:Journal of neuroimmunology

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    authors: Yuhas Y,Ashkenazi S,Berent E,Weizman A

    更新日期:2017-04-15 00:00:00

  • MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages.

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    pub_type: 杂志文章


    authors: Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

    更新日期:2020-06-15 00:00:00

  • Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus.

    abstract::Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

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    authors: Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

    更新日期:1984-09-01 00:00:00

  • Chronic electrical stimulation of the lateral hypothalamus increases natural killer cell cytotoxicity in rats.

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    journal_title:Journal of neuroimmunology

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    authors: Wrona D,Trojniar W

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  • Cytokine-like effects of prolactin in human mononuclear and polymorphonuclear leukocytes.

    abstract::Some biochemical events following the binding of prolactin (PRL) to its receptor in normal human leukocytes were investigated. PRL enhanced JAK2 phosphorylation in peripheral blood mononuclear cells (PBMC) but not in granulocytes. PRL also induced phosphorylation of Stat-5 in PBMC and Stat-1 in granulocytes. Subsequen...

    journal_title:Journal of neuroimmunology

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    authors: Dogusan Z,Hooghe R,Verdood P,Hooghe-Peters EL

    更新日期:2001-11-01 00:00:00

  • Combination therapy in multiple sclerosis.

    abstract::The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

    journal_title:Journal of neuroimmunology

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    authors: Milo R,Panitch H

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  • Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.

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    authors: Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

    更新日期:1997-06-01 00:00:00

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    abstract::We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histolo...

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    pub_type: 杂志文章


    authors: Kim HJ,Jung CG,Dukala D,Bae H,Kakazu R,Wollmann R,Soliven B

    更新日期:2009-09-29 00:00:00

  • Interleukin-1 activity in lesioned peripheral nerve.

    abstract::The cytokine interleukin-1 (IL-1) is involved in a wide range of inflammatory and immune responses. As such, IL-1 could play a role in peripheral nerve repair mechanisms. Specifically, by its already established properties as a regulator of nerve growth factor (NGF) synthesis, and as a chemotactant to macrophages. We ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rotshenker S,Aamar S,Barak V

    更新日期:1992-07-01 00:00:00

  • Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis.

    abstract::We studied the effects of combination treatment with an anti-inflammatory agent, interferon (IFN)-beta, and a putative neuroprotective agent, an estrogen receptor (ER)-beta ligand, during EAE. Combination treatment significantly attenuated EAE disease severity, preserved axonal densities in spinal cord, and reduced CN...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Du S,Sandoval F,Trinh P,Voskuhl RR

    更新日期:2010-02-26 00:00:00

  • Soluble Fas (Apo-1) levels in cerebrospinal fluid of multiple sclerosis patients.

    abstract::CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant co...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi A

    更新日期:1998-02-01 00:00:00

  • Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway.

    abstract::The microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) or Rho/Rho kinase (ROCK) are both involved in the development of non-specific inflammation. However, there are few...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Chen J,Sun Z,Jin M,Tu Y,Wang S,Yang X,Chen Q,Zhang X,Han Y,Pi R

    更新日期:2017-04-15 00:00:00