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Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India.

Abstract：

:Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T cells, while activated CD8 and memory regulatory T cells (Tregs) were increased in women with PP as against healthy controls. The CD14-CD16+non-classical monocytes, CD11c+myeloid DCs and cytotoxic CD56dimCD16+ were reduced, while CD56brtCD16+/-regulatory NK cells were elevated in women with PP. The variations in immune cell subsets highlight the generalized immune dysregulation in PP.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

doi

10.1016/j.jneuroim.2017.06.002

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

8-13

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(17)30145-5

journal_volume

310

pub_type

杂志文章

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