当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM.

Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM.

Abstract：

:The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturally occurring neuropeptide, beta-endorphin, reduced the incidence of JHMV-induced paralytic-demyelinating disease 40-50% in C57Bl/6 mice. Protection from disease was accompanied by significantly reduced virus replication in the brain as early as 3 days post-infection and did not occur in irradiated, or immunoincompetent mice. The data suggest that beta-endorphin engages immune mechanisms of host resistance to JHMV infection to protect the mice from disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Gilmore W,Moradzadeh DS

doi

10.1016/0165-5728(93)90061-3

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

81-90

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(93)90061-3

journal_volume

48

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.

    abstract：:A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of signif...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.03.020

    authors： Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

    更新日期：2010-06-01 00:00:00

  • Cyclophosphamide alters the clinical and pathological expression of experimental autoimmune gray matter disease.

    abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90123-o

    authors： Tajti J,Stefani E,Appel SH

    更新日期：1991-11-01 00:00:00

  • A genome screen for linkage disequilibrium in Turkish multiple sclerosis.

    abstract：:In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for as...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jneuroim.2003.08.027

    authors： Eraksoy M,Hensiek A,Kurtuncu M,Akman-Demir G,Kilinc M,Gedizlioglu M,Petek-Balci B,Anlar O,Kutlu C,Saruhan-Direskeneli G,Idrisoglu HA,Setakis E,Compston A,Sawcer S,Turkish Multiple Sclerosis Genetics Study Group.

    更新日期：2003-10-01 00:00:00

  • Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

    abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.05.012

    authors： Tsunoda I,Libbey JE,Fujinami RS

    更新日期：2007-08-01 00:00:00

  • Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: implications for myelination.

    abstract：:Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.05.021

    authors： Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

    更新日期：2006-09-01 00:00:00

  • (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.

    abstract：:A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.03.011

    authors： Fu YF,Zhu YN,Ni J,Zhong XG,Tang W,Zhou R,Zhou Y,Dong JR,He PL,Wan H,Li YC,Yang YF,Zuo JP

    更新日期：2006-06-01 00:00:00

  • The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

    abstract：:Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate ph...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.04.019

    authors： Phan TA,Taylor AW

    更新日期：2013-07-15 00:00:00

  • Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis.

    abstract：:Little is known about the involvement of cytokines in the pathogenesis of primary progressive (PP) multiple sclerosis (MS). We evaluated in this cross-sectional study whether IL-18, IL-12p35, IL-12p40, TNF-alpha, IFN-gamma, IL-10, IL-4, TGF-beta, IL-12Rbeta1, and IL-12Rbeta2 mRNA expression in unstimulated white blood...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00398-8

    authors： van Boxel-Dezaire AH,Smits M,van Trigt-Hoff SC,Killestein J,van Houwelingen JC,Polman CH,Nagelkerken L

    更新日期：2001-11-01 00:00:00

  • Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) of the Lewis rat.

    abstract：:Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflam...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00039-8

    authors： Enders U,Toyka KV,Hartung HP,Gold R

    更新日期：1997-06-01 00:00:00

  • Successful combined treatment with thymectomy, rituximab and tocilizumab for severe thymoma-associated multi autoimmune syndrome.

    abstract：:We present a 53-year-old woman who presented simultaneously with acute inflammatory demyelinating polyneuropathy, Graves' disease, leukocytoclastic vasculitis, elevated acetylcholine antibody receptor antibodies and a mediastinal mass. Thymectomy was performed and revealed a type A thymoma and the clinical picture and...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.577028

    authors： Sveinsson O,Piehl F,Aspegren O,Hietala MA

    更新日期：2019-11-15 00:00:00

  • Cytokine profile in patients with multiple sclerosis following vitamin D supplementation.

    abstract：:Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-5728(02)00396-x

    authors： Mahon BD,Gordon SA,Cruz J,Cosman F,Cantorna MT

    更新日期：2003-01-01 00:00:00

  • Differential binding patterns of anti-sulfatide antibodies to glial membranes.

    abstract：:Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.07.004

    authors： Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

    更新日期：2018-10-15 00:00:00

  • IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay.

    abstract：:We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negativ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.10.013

    authors： Kadoya M,Kaida K,Koike H,Takazaki H,Ogata H,Moriguchi K,Shimizu J,Nagata E,Takizawa S,Chiba A,Yamasaki R,Kira JI,Sobue G,Ikewaki K

    更新日期：2016-12-15 00:00:00

  • Temporal variations of adhesion molecules and matrix metalloproteinases in the course of MS.

    abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00204-2

    authors： Correale J,Bassani Molinas Mde L

    更新日期：2003-07-01 00:00:00

  • Comparative binding of murine and human monoclonal antibodies reacting with myelin-associated glycoprotein to myelin and human lymphocytes.

    abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90118-4

    authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

    更新日期：1987-07-01 00:00:00

  • Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients.

    abstract：:The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.05.004

    authors： Krestova M,Ricny J,Bartos A

    更新日期：2018-09-15 00:00:00

  • A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein.

    abstract：:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2003.12.007

    authors： Mendel I,Natarajan K,Ben-Nun A,Shevach EM

    更新日期：2004-04-01 00:00:00

  • Transient in vivo activation of rat brain macrophages/microglial cells and astrocytes by immunostimulatory multiple CpG oligonucleotides.

    abstract：:Certain DNA sequences containing motifs of unmethylated CpG nucleotides are immunostimulatory and might contribute to the development of inflammatory lesions after infections. CpG motifs might further contribute to side effects of oligonucleotide-based therapeutic approaches. Here we have analyzed the effects of intra...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00428-8

    authors： Schluesener HJ,Seid K,Deininger M,Schwab J

    更新日期：2001-02-01 00:00:00

  • Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.

    abstract：:Ischemic stroke is one of the leading causes of mortality and morbidity in humans. During brain ischemia and the subsequent reperfusion that occurs with stroke, the generation of the so-called "proinflammatory" prostaglandin E(2) (PGE(2)) increases significantly. Therefore, interest is growing regarding the differenti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.01.015

    authors： Saleem S,Kim YT,Maruyama T,Narumiya S,Doré S

    更新日期：2009-03-31 00:00:00

  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.

    abstract：:Thymic tissues express transcripts encoding the alpha-3, alpha-5 and beta-4 subunits of nicotinic neuronal acetylcholine receptors (AcChRs) suggesting that neuronal AcChRs similar to those expressed in ganglia are expressed in the thymus. Transcription occurs in both isolated thymocytes and thymic epithelial cells. RT...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00120-3

    authors： Mihovilovic M,Denning S,Mai Y,Whichard LP,Patel DD,Roses AD

    更新日期：1997-11-01 00:00:00

  • Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis.

    abstract：:We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples wer...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0165-5728(96)00206-8

    authors： Pitzalis C,Sharrack B,Gray IA,Lee A,Hughes RA

    更新日期：1997-04-01 00:00:00

  • Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice.

    abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.04.006

    authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

    更新日期：2005-07-01 00:00:00

  • Cytokine-like effects of prolactin in human mononuclear and polymorphonuclear leukocytes.

    abstract：:Some biochemical events following the binding of prolactin (PRL) to its receptor in normal human leukocytes were investigated. PRL enhanced JAK2 phosphorylation in peripheral blood mononuclear cells (PBMC) but not in granulocytes. PRL also induced phosphorylation of Stat-5 in PBMC and Stat-1 in granulocytes. Subsequen...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00420-9

    authors： Dogusan Z,Hooghe R,Verdood P,Hooghe-Peters EL

    更新日期：2001-11-01 00:00:00

  • Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis.

    abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.01.008

    authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

    更新日期：2004-05-01 00:00:00

  • Role of the Programmed Death-1 (PD-1) pathway in regulation of Theiler's murine encephalomyelitis virus-induced demyelinating disease.

    abstract：:Programmed death-1 (PD-1) belongs to the CD28 family of co-stimulatory and co-inhibitory molecules and regulates adaptive immunity. This molecule induces the development of regulatory T cells, T cell tolerance, or apoptosis. We examined the role of PD-1 pathway in Theiler's murine encephalomyelitis virus (TMEV)-induce...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.06.018

    authors： Takizawa S,Kaneyama T,Tsugane S,Takeichi N,Yanagisawa S,Ichikawa M,Yagita H,Kim BS,Koh CS

    更新日期：2014-09-15 00:00:00

  • Immunocytochemical characterisation of cell cultures grown from dissociated 1-2-day post-natal rat cerebral tissue. A developmental study.

    abstract：:A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(84)80002-8

    authors： Walker AG,Chapman J,Bruce CB,Rumsby MG

    更新日期：1984-11-01 00:00:00

  • TNF and sTNFR1/2 plasma levels in ALS patients.

    abstract：:The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.10.028

    authors： Cereda C,Baiocchi C,Bongioanni P,Cova E,Guareschi S,Metelli MR,Rossi B,Sbalsi I,Cuccia MC,Ceroni M

    更新日期：2008-02-01 00:00:00

  • Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines.

    abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00106-x

    authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

    更新日期：1999-09-01 00:00:00

  • Corticotropin-releasing hormone is involved in conditioned stimulus-induced reduction of natural killer cell activity but not in conditioned alterations in cytokine production or proliferation responses.

    abstract：:Research from our laboratory has demonstrated that the presentation of an aversive conditioned stimulus produces pronounced suppression of several in vitro measures of immune status. The present study was designed to evaluate the role of central corticotropin-releasing hormone (CRH) in the mechanisms mediating these c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00119-0

    authors： Perez L,Lysle DT

    更新日期：1995-12-01 00:00:00

  • Human B cell lines secreting IgM antibody specific for myelin basic protein.

    abstract：:In this study we describe for the first time the production of stable human B cell lines and clones that secrete IgM antibody specific for human myelin basic protein. The technique based on limiting dilutions of Epstein-Barr virus-transformed peripheral B cells from patients with multiple sclerosis, precluded the need...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90092-1

    authors： Zhang JW,Lambrechts J,Heyligen H,Vandenbark AA,Raus JC

    更新日期：1989-09-01 00:00:00