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Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: implications for myelination.

Abstract：

:Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express CXC chemokine receptors led us to the investigation of the expression and functional importance of CC chemokine receptors. Using RT-PCR, we show that primary OPC from neonatal rats express CCR3, while CCR1, CCR2, CCR4, CCR5, and CCR7 are not expressed. Immunofluorescence staining of OPC could further demonstrate protein expression of CCR3. A rise of intracellular Ca2+ upon stimulation with the appropriate ligand CCL11 showed that this receptor is functional. Moreover, CCL11 led to a concentration specific increase in proliferation, inhibition of migration, and augmentation of differentiation in primary OPC. Thus, CCR3 may influence the process of myelination. This is of general importance for both developmental tissue patterning and for repair processes in demyelinating diseases like multiple sclerosis.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

doi

10.1016/j.jneuroim.2006.05.021

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

17-23

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00205-0

journal_volume

178

pub_type

杂志文章

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