Abstract:
:Macrophages are considered to be the predominant effector cells in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Ultra small particles of iron oxide (USPIO) can be used to detect macrophage infiltrates in the CNS with magnetic resonance imaging (MRI). Here, we investigated whether the kinetics of lesion formation in EAE can be visualised by altering the time point of USPIO injection and the time interval between particle injection and MRI. When USPIO are systemically injected 24 h before MRI, hypo intense regions are detected in different brain regions depending on the disease stage. These regions correspond to sites of macrophage infiltration. A more complete visualisation of sites of inflammation is accomplished by USPIO injection at disease onset and postponing MRI to top of disease. This study demonstrates that the distribution pattern and amount of inflammatory lesions detected with USPIO, depends on timing of USPIO administration and subsequent MRI. These findings are important for a correct application and interpretation of USPIO dependent contrast imaging of CNS inflammation.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Baeten K,Hendriks JJ,Hellings N,Theunissen E,Vanderlocht J,Ryck LD,Gelan J,Stinissen P,Adriaensens Pdoi
10.1016/j.jneuroim.2007.11.008subject
Has Abstractpub_date
2008-03-01 00:00:00pages
1-6issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(07)00401-8journal_volume
195pub_type
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更新日期:1994-07-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.12.009
更新日期:2015-01-15 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2015-01-15 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00