当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response.

Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response.

Abstract：

:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active drug. The most common adverse event was transient injection site reactions. Non-significant trend for increases in serum levels of IL-3, IL-13, and CCL22 over time were suggestive of a beneficial T(H)2 immune response in subjects dosed with PI-2301 at 3 and 10 mg. MRI data indicated a non-significant trend for a reduction of lesion numbers in subjects treated with 1 and 3 mg PI-2301.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

doi

10.1016/j.jneuroim.2010.04.008

subject

Has Abstract

pub_date

2010-08-25 00:00:00

pages

153-63

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00168-2

journal_volume

225

pub_type

杂志文章,随机对照试验

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