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On classification of post-mortem multiple sclerosis plaques for neuroscientists.

Abstract：

:Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility Complex (MHC) Class II molecule, HLA-DR, and by Oil Red O staining, respectively. 40% of the plaques were inactive. This result highlights the need for a description of plaque activity for studies of the etiopathogenesis of MS; that is, the earliest and/or the most active plaques should contain the causative agent whereas the burnt out plaques should not.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sanders V,Conrad AJ,Tourtellotte WW

doi

10.1016/0165-5728(93)90251-s

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

207-16

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(93)90251-S

journal_volume

46

pub_type

杂志文章

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